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Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson's disease
Levodopa helps in reducing the frequency and duration of ‘off’‐related FOG and distinction amongst FOG subtypes enables evaluation of distinctive therapeutic response. Expand
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.
Data collected demonstrate that there is a strong association between GBA mutations and Parkinson's disease, and those with a GBA mutation presented earlier with the disease, were more likely to have affected relatives, and were morelikely to have atypical clinical manifestations. Expand
Impaired regulation of stride variability in Parkinson's disease subjects with freezing of gait
It is found that the ability to regulate the stride-to-stride variations in gait timing and maintain a stable walking rhythm is markedly impaired in subjects with freezing of gait, and the inability to control cadence might play an important role in this debilitating phenomenon. Expand
The natural history of multiple system atrophy: a prospective European cohort study
The final analysis of a prospective multicentre study by the European MSA Study Group provides new insights into the evolution of MSA based on a follow-up period that exceeds that of previous studies. Expand
Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset
Genotype-phenotype correlations between different GBA mutations and Parkinson disease (PD) risk and AAO in Ashkenazi Jews are demonstrated and an earlier AAO was observed in LRRK2 G2019S carrier PD patients. Expand
Presentation, diagnosis, and management of multiple system atrophy in Europe: Final analysis of the European multiple system atrophy registry
This largest clinical series of MSA patients reported so far shows that the disease presents uniformly across Europe, and the observed differences in diagnostic and therapeutic management including lack of therapy for dysautonomia emphasize the need for future guidelines in these areas. Expand
Can an accelerometer enhance the utility of the Timed Up & Go Test when evaluating patients with Parkinson's disease?
INTRODUCTION The Timed Up and Go (TUG) test is a widely used measure of mobility and fall risk in older adults and in Parkinson's disease (PD). We tested the hypothesis that body-fixed accelerometersExpand
Red flags for multiple system atrophy
A combination of two out of six red flag categories as additional diagnostic criteria for probable MSA‐P is proposed and 76.5% of them would have been correctly diagnosed as probable Msa‐P 15.9 months earlier than with the Consensus criteria alone. Expand
Subjective memory complaints in elders: depression, anxiety, or cognitive decline?
To study the association of subjective memory complaints (SMC) with affective state and cognitive performance in elders, a large number of elders were surveyed and it was found that the number of complaints was higher in elders with a negative affect than in those with a positive one. Expand
Gait instability and fractal dynamics of older adults with a "cautious" gait: why do certain older adults walk fearfully?
The hypothesis that temporal gait variability is increased among older adults with a cautious gait and a higher-level gait disorder (HLGD) is tested, suggesting that the gait changes in older adults who walk with fear may be an appropriate response to unsteadiness, are likely a marker of underlying pathology, and are not simply a physiological or psychological consequence of normal aging. Expand