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A multigenic program mediating breast cancer metastasis to bone.
We investigated the molecular basis for osteolytic bone metastasis by selecting human breast cancer cell line subpopulations with elevated metastatic activity and functionally validating genes thatExpand
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Bisphosphonate‐Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research
ONJ has been increasingly suspected to be a potential complication of bisphosphonate therapy in recent years. Thus, the ASBMR leadership appointed a multidisciplinary task force to address keyExpand
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Cancer to bone: a fatal attraction
When cancer metastasizes to bone, considerable pain and deregulated bone remodelling occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and sculpt the boneExpand
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Diagnosis and Management of Osteonecrosis of the Jaw: A Systematic Review and International Consensus
This work provides a systematic review of the literature from January 2003 to April 2014 pertaining to the incidence, pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), andExpand
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Cancer and bone.
I. Introduction II. Normal Calcium and Bone Homeostasis A. Bone remodeling B. Calcium homeostasis C. Defenses against hyper- and hypocalcemia III. Humoral Mechanisms by Which Solid Tumors Affect theExpand
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Modulation of mammalian life span by the short isoform of p53.
Overexpression of the short isoform of p53 (p44) has unexpectedly uncovered a role for p53 in the regulation of size and life span in the mouse. Hyperactivation of the insulin-like growth factorExpand
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Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis.
Breast cancer almost invariably metastasizes to bone in patients with advanced disease and causes local osteolysis. Much of the morbidity of advanced breast cancer is a consequence of this process.Expand
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Guide to bone health and disease in cystic fibrosis.
Cystic fibrosis (CF) is the most common genetic disease within the Caucasian population and leads to premature respiratory failure. Approximately 60,000 individuals are currently living with CF inExpand
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Basic Mechanisms Responsible for Osteolytic and Osteoblastic Bone Metastases
Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of aExpand
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