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Elicitation of secondary metabolism in actinomycetes.
- U. Abdelmohsen, T. Grkovic, S. Balasubramanian, M. Kamel, R. Quinn, U. Hentschel
- Biology, Medicine
- Biotechnology advances
- 1 November 2015
This review focuses on the effects of biological, chemical, as well as molecular elicitation on secondary metabolism in actinomycetes and exemplifies the diversity of natural products that have been recovered by such approaches from the phylum Actinobacteria. Expand
Production of Induced Secondary Metabolites by a Co-Culture of Sponge-Associated Actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163
- Yousef Dashti, T. Grkovic, U. Abdelmohsen, U. Hentschel, R. Quinn
- Medicine, Biology
- Marine drugs
- 1 May 2014
Two sponge-derived actinomycetes, Actinokineospora sp. EG49 and Nocardiopsis sp. RV163, were grown in co-culture and the presence of induced metabolites monitored by 1H NMR. Ten known compounds,… Expand
Enantiomeric discorhabdin alkaloids and establishment of their absolute configurations using theoretical calculations of electronic circular dichroism spectra.
- T. Grkovic, Yuanqing Ding, X. Li, V. Webb, D. Ferreira, B. Copp
- Chemistry, Medicine
- The Journal of organic chemistry
- 15 October 2008
Enantiomeric pairs of the cytotoxic pyrroloiminoquinone marine alkaloids discorhabdins have been isolated from Latrunculia species sponges collected around the coast of New Zealand and exhibit equipotent antiproliferative biological activity. Expand
National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library
Overall, the rapid second-stage purification conserves extract mass, requires much less chemist time, and introduces knowledge of structure early in the isolation workflow. Expand
Anti-staphylococcal activity of C-methyl flavanones from propolis of Australian stingless bees (Tetragonula carbonaria) and fruit resins of Corymbia torelliana (Myrtaceae).
Ethanolic preparations of propolis were shown to be active against Staphylococcus aureus and to a lesser extent against Pseudomonas aeruginosa and C. torelliana flavanones inhibited the growth of S. aureu therefore contributing to the antibacterial effects observed for Australian stingless bee propolis extracts. Expand
Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1α/p300 Interaction.
Pyrroloiminoquinone alkaloid alkaloids are a novel class of HIF-1α inhibitors, which interrupt the protein-protein interaction between Hif-1 α and p300 and consequently reduce H IF-related transcription. Expand
NMR Fingerprints of the Drug-like Natural-Product Space Identify Iotrochotazine A: A Chemical Probe to Study Parkinson’s Disease**
An NMR fingerprint method is presented that takes advantage of the fact that fractions contain simplified NMR profiles, with minimal signal overlap, to allow the identification of unique spectral patterns in a novel natural product. Expand
Predicting natural product value, an exploration of anti-TB drug space.
A perspective based on an analysis of the drug-like properties of the reported anti-mycobacterium natural products is presented in order to assess drug potential. Expand
A model to predict anti-tuberculosis activity: value proposition for marine microorganisms
- Miaomiao Liu, T. Grkovic, Lixin Zhang, Xueting Liu, R. Quinn
- Biology, Medicine
- The Journal of Antibiotics
- 13 July 2016
It is shown that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space, and a model to predict potential anti- TB drugs is proposed. Expand
Chemistry and Chemical Ecology of some of the Common Opisthobranch Molluscs Found on the Shores of NE New Zealand
Marine natural products have been assigned various ecological roles such as predator deterrence, mediation of competition, facilitation of reproduction, inhibition of overgrowth, protection from ultraviolet radiation, defense against pathogens and the induction of settlement. Expand