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The genome sequence of Atlantic cod reveals a unique immune system
TLDR
The genome sequence of Atlantic cod is presented, showing evidence for complex thermal adaptations in its haemoglobin gene cluster and an unusual immune architecture compared to other sequenced vertebrates. Expand
The fusion of early endosomes induces molecular-motor-driven tubule formation and fission
TLDR
The results show that fusion of endosomes is a rapid process that destabilizes the membrane and instantly induces molecular-motor-driven tubule formation and fission. Expand
EDEM is involved in retrotranslocation of ricin from the endoplasmic reticulum to the cytosol.
TLDR
Results indicate that EDEM is involved in retrotranslocation of ricin from the ER to the cytosol, and vector-based RNA interference against EDEM, which leads to reduction of the cellular level ofEDEM, decreased retrotrans Location of Ricin A-chain to the Cytosol. Expand
The cytoplasmic tail of invariant chain regulates endosome fusion and morphology.
The major histocompatibility complex class II associated invariant chain (Ii) has been shown to inhibit endocytic transport and to increase the size of endosomes. We have recently found that thisExpand
MHC II and the Endocytic Pathway: Regulation by Invariant Chain
TLDR
The invariant chain provides a scaffold for the assembly of three MHC II heterodimers and blocks their peptide binding grooves, thereby avoiding premature peptidebinding. Expand
Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments
TLDR
expression of a dominant-negative (K71M) green fluorescent protein-tagged version of hsc70 counteracted the ability of Ii to modify the endocytic pathway, demonstrating an interaction in vivo of I i with hsc 70 as part of the machinery responsible for macrosome formation. Expand
The Mitogen-activated protein kinase p38 links Shiga Toxin-dependent signaling and trafficking.
TLDR
It is demonstrated that transport of Stx to the Golgi apparatus is dependent on the mitogen-activated protein kinase p38, and evidence is provided that Stx activates a signaling cascade involving cross talk between Ca(2+) and p 38, to regulate its trafficking to the golgi apparatus. Expand
Evolutionary redesign of the Atlantic cod (Gadus morhua L.) Toll-like receptor repertoire by gene losses and expansions
TLDR
A comprehensive vertebrate TLR phylogeny reveals that the Atlantic cod TLR repertoire is extreme with regards to losses and expansions compared to other teleosts and provides new insight into the function and evolution of TLRs in Atlantic cod as well as the evolutionary history of vertebrate innate immunity. Expand
Unraveling the Evolution of the Atlantic Cod’s (Gadus morhua L.) Alternative Immune Strategy
TLDR
A novel combination of two endosomal sorting motifs, one tyrosine- based associated with exogenous peptide presentation by cross-presenting MHCI molecules, and one dileucine-based associated with normal MHC II functionality are identified in the cytoplasmic tail in a subset of the genes, indicating that these genes have evolved M HC II-like functionality, allowing a more versatile use of MHC I through cross- presentation. Expand
The cytoplasmic tail of invariant chain modulates antigen processing and presentation
TLDR
It is found that degradation of both endocytosed antigen and Ii itself is delayed in cells expressing high levels of Ii, whereas a mutant Ii with an altered charge distribution in the cytoplasmic tail was unable to exert this effect. Expand
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