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Leaderless Transcripts and Small Proteins Are Common Features of the Mycobacterial Translational Landscape
The translational-reporter system indicates that mycobacterial leadered translation initiation requires a Shine Dalgarno site in the 5’ UTR and that ATG, GTG, TTG, and ATT codons can robustly initiate translation. Expand
Imprinting-mutation mechanisms in Prader-Willi syndrome.
- T. Ohta, T. Gray, +10 authors R. Nicholls
- Biology, Medicine
- American journal of human genetics
- 1 February 1999
It is suggested that promoter elements at SNRPN play a key role in the initiation of imprint switching during spermatogenesis, since the epigenetic effect of an IM in the parental germ line determines the phenotypic effect in the patient. Expand
The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.
The ancient origin of MKRN1, high degree of conservation, and expression pattern suggest important developmental and functional roles for this gene and its expressed family members. Expand
An imprinted, mammalian bicistronic transcript encodes two independent proteins.
- T. Gray, S. Saitoh, R. Nicholls
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 11 May 1999
Phylogenetic analysis of the SNRPN (SmN) mRNA in five eutherian mammals reveals a second highly conserved coding sequence, termed SNURF (SNRPN upstream reading frame), which is identified as a protein that is produced along with SmN from a bicistronic transcript. Expand
A novel imprinted gene, encoding a RING zinc-finger protein, and overlapping antisense transcript in the Prader-Willi syndrome critical region.
ZNF127 and ZNF127AS are novel imprinted genes that may be associated with some of the clinical features of the polygenic Prader-Willi syndrome. Expand
Distributive Conjugal Transfer in Mycobacteria Generates Progeny with Meiotic-Like Genome-Wide Mosaicism, Allowing Mapping of a Mating Identity Locus
- T. Gray, Janet A. Krywy, J. Harold, M. Palumbo, K. Derbyshire
- Medicine, Biology
- PLoS biology
- 1 July 2013
We find that genome-wide DNA transfer by conjugation in mycobacteria affords bacteria that reproduce by binary fission the same advantages of sexual reproduction, and may explain the genomic… Expand
Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames.
The data presented here demonstrate a very highly conserved and physiologically relevant dynamic splicing scheme that profoundly influences the protein-coding potential of the MOCS1 locus. Expand
Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci.
Western analysis demonstrates that a compensatory feedback loop dramatically upregulates SmB'/B levels in response to the loss of SmN in Prader-Willi syndrome brain tissue, potentially reducing the phenotypic severity of this syndrome. Expand
Zinc depletion induces ribosome hibernation in mycobacteria
- Yunlong Li, Manjuli R. Sharma, +8 authors A. K. Ojha
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences
- 23 July 2018
The remodeled ribosome acquires a structurally stable but functionally inactive and aminoglycoside-resistant state in zinc-starved Mycobacterium smegmatis and is the exclusive target of a bacterial protein Y homolog, referred to as mycobacterial-specific protein Y (MPY), which binds to the decoding region of the 30S subunit, thereby inactivating the ribosomes. Expand
Polar assembly and scaffolding proteins of the virulence‐associated ESX‐1 secretory apparatus in mycobacteria
- S. Wirth, Janet A. Krywy, +4 authors K. Derbyshire
- Biology, Medicine
- Molecular microbiology
- 1 February 2012
It is shown that fluorescently tagged proteins required for ESX‐1 activity consistently localize to the cell pole, identified by time‐lapse fluoro‐microscopy as the non‐septal (old) pole, illustrating the cross‐species conservation of protein interactions governing assembly of ESX-1, as well as polar localization. Expand