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Host circadian clock as a control point in tumor progression.
TLDR
Disruption of circadian rhythms in mice was associated with accelerated growth of malignant tumors of two types, suggesting that the host circadian clock may play an important role in endogenous control of tumor progression. Expand
Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases*
TLDR
A combination of virtual screening and molecular modeling led to the development of a structure-activity relationship, which indicated the preferred substituents on the pyrazolopyrimidine scaffold that leads to the synthesis of ETP-45658, which is a potent and selective inhibitor of phosphoinositide 3-kinases and demonstrates mechanism of action in tumor cell lines and in vivo in treated mice. Expand
Persistent twenty-four hour changes in liver and bone marrow despite suprachiasmatic nuclei ablation in mice.
TLDR
The results suggest that the delivery of anticancer treatments at an optimal time of day may still be beneficial, despite suppressed rest-activity or cortisol rhythms, and support the existence of another light-dark entrainable pacemaker that can coordinate cellular functions in peripheral organs. Expand
Disruption of circadian coordination accelerates malignant growth in mice.
TLDR
It is shown that disruption of circadian coordination accelerates malignant growth in mice, suggesting that the host circadian clock controls tumor progression. Expand
Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma
TLDR
Irinotecan addition to oxaliplatin proved therapeutic benefit only if the schedule consisted of irinot Cecan administration at 7 hours after light onset and oxali Platin delivery at 15 hours afterLight onset, i.e. when both drugs were given near their respective ‘best’ circadian times. Expand
Tumor-based rhythms of anticancer efficacy in experimental models
TLDR
Results of laboratory animal studies have been extrapolated to the design of clinical cancer therapy trials involving a chronobiological approach and the usual coupling between tolerability and efficacy rhythms of anticancer agents has resulted in significant improvement of their therapeutic index. Expand
Experimental chronotherapy of mouse mammary adenocarcinoma MA13/C with docetaxel and doxorubicin as single agents and in combination.
TLDR
Single agent docetaxel or doxorubicin as a single drug was significantly best tolerated near the middle of the rest span (7 HALO) and most toxic in themiddle of the activity phase (19 HALO). Expand
Biological characterization of ETP-46321 a selective and efficacious inhibitor of phosphoinositide-3-kinases
TLDR
ETP-46321 inhibited PI3K signaling in treated tumor cell lines, induced cell cycle arrest and inhibited VEGF-dependent sprouting of HUVEC cells and synergized with both cytotoxic and targeted therapeutics. Expand
Variations and interrelation between vasopressin and plasma osmolality in diabetic rats with insulin treatment.
TLDR
In uncontrolled diabetic rats, the higher VP levels and the loss of VP circadian rhythmicity could be due to a higher sensitivity in the osmoregulatory system, together with an absence of circadian variation of this system. Expand
Circadian Rhythms of Plasma Concentrations of Na+ and K+ and Their Urinary Excretion in Normal and Diabetic Rats
TLDR
The effects of streptozotocin induced diabetes on the circadian rhythms in the excretion of sodium and potassium as well as their plasma concentration rhythms were investigated and may suggest that the glomerular filtration system in diabetic rats is responsible for this rhythmicity. Expand
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