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Brain Inflammation in Epilepsy: Experimental and Clinical Evidence
TLDR
The possibility that inflammation may be a common factor contributing, or predisposing, to the occurrence of seizures and cell death, in various forms of epilepsy of different etiologies is discussed. Expand
Pathogenesis, diagnosis and treatment of Rasmussen encephalitis: a European consensus statement.
TLDR
This work proposes formal diagnostic criteria and a therapeutic pathway for the management of RE patients, and summarizes recent data on the pathogenesis, clinical and paraclinical presentation, and therapeutic approaches. Expand
Congenital malformations due to antiepileptic drugs
TLDR
The results indicate that the increased incidence of congenital malformations was caused primarily by AEDs, suggesting that mal Formations can be prevented by improvements in drug regimen, and by avoiding polypharmacy and high levels of VPA in the treatment of epileptic women of childbearimg age. Expand
Seizure‐Promoting Effect of Blood–Brain Barrier Disruption
TLDR
It is generally accepted that blood–brain barrier (BBB) failure occurs as a result of CNS diseases, including epilepsy, but evidences also suggest that BBB failure may be an etiological factor contributing to the development of seizures. Expand
De novo mutations in ATP1A3 cause alternating hemiplegia of childhood
TLDR
De novo ATP1A3 mutations are identified as the primary cause ofAlternating hemiplegia of childhood and insight into disease pathophysiology is offered by expanding the spectrum of phenotypes associated with mutations in ATP 1A3. Expand
Epileptic phenotypes associated with mitochondrial disorders
TLDR
Epilepsy is an important sign in the early presentation of ME and may be the most apparent neurologic sign of nontypical ME, often leading to the diagnostic workup. Expand
Antagonism of peripheral inflammation reduces the severity of status epilepticus
TLDR
The hypothesis that intravenous administration of IL-1 receptor antagonists (IL-1ra) may prevent pilocarpine-induced seizures is tested and the concept of targeting systemic inflammation and BBB for the prevention of status epilepticus is supported. Expand
Spectrum of SCN1A mutations in severe myoclonic epilepsy of infancy
TLDR
A greater frequency of unilateral motor seizures was the only clinical difference between patients with SCN1A mutations and those without, suggesting that SMEI is genetically heterogeneous. Expand
Dravet syndrome: Early clinical manifestations and cognitive outcome in 37 Italian patients
TLDR
The data indicate that the most striking features of SMEI are: the early onset of seizures in a previously healthy child, the long duration of the first seizure, the presence of focal ictal symptoms, and sensitivity to low-grade fever. Expand
Band heterotopia: Correlation of outcome with magnetic resonance imaging parameters
TLDR
The clinical records and magnetic resonance imaging studies of 27 patients with band heterotopia were retrospectively reviewed in an attempt to determine whether imaging findings are useful in predicting clinical outcome of affected patients. Expand
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