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RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional cloningExpand
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Dilemmas in the diagnosis and treatment of intracranial tuberculomas
Tuberculosis (TB) remains a major public health problem across the globe. A common form of extrapulmonary TB (EPTB) with high mortality and morbidity is neuro TB or tuberculosis of the nervousExpand
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Karyotaxonomy of South Indian Balsaminaceae
Cytological studies with special reference to karyotaxonomy have been made in 14 taxa. First record of chromosome numbers has been made in 4 species and in the rest of the taxa studied, the presentExpand
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Karyomorphological Studies in South Indian Acanthaceae
The chromosome number of 30 species belonging to 16 genera of Acanthaceae from South India has been studied. Chromosome numbers determined in the present study range from 2n=16 to 2n=60.ChromosomeExpand
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Interspecies Differences in Virus Uptake versus Cardiac Function of the Coxsackievirus and Adenovirus Receptor
ABSTRACT The coxsackievirus and adenovirus receptor (CAR) is a cell contact protein with an important role in virus uptake. Its extracellular immunoglobulin domains mediate the binding toExpand
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publication in Nature Medicine,18, 766-773 (2012)
Alternative splicing has a major role in cardiac adaptive responses, as exemplified by the isoform switch of the sarcomeric protein titin, which adjusts ventricular filling. By positional cloningExpand
A novel Splicing Factor that Affects Titin Alternative Splicing
Cardiac muscle expresses predominantly larger N2BA titin isoforms at embryonic and prenatal stages of development, and these are mostly replaced with a smaller N2B isoform in adults. We haveExpand