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Spondylodiscitis: update on diagnosis and management.
Spondylodiscitis, a term encompassing vertebral osteomyelitis, spondylitis and discitis, is the main manifestation of haematogenous osteomyelitis in patients aged over 50 years. Staphylococcus aureus… Expand
Rapid bacterial whole-genome sequencing to enhance diagnostic and public health microbiology.
IMPORTANCE The latest generation of benchtop DNA sequencing platforms can provide an accurate whole-genome sequence (WGS) for a broad range of bacteria in less than a day. These could be used to more… Expand
Genome-based characterization of hospital-adapted Enterococcus faecalis lineages
Vancomycin-resistant Enterococcus faecalis (VREfs) is an important nosocomial pathogen1,2. We undertook whole genome sequencing of E. faecalis associated with bloodstream infection in the UK and… Expand
One Health Genomic Surveillance of Escherichia coli Demonstrates Distinct Lineages and Mobile Genetic Elements in Isolates from Humans versus Livestock
The increasing prevalence of E. coli bloodstream infections is a serious public health problem. We used genomic epidemiology in a One Health study conducted in the East of England to examine putative… Expand
Prevention and treatment of Clostridium difficile infection.
Use of Vitek 2 Antimicrobial Susceptibility Profile To Identify mecC in Methicillin-Resistant Staphylococcus aureus
- E. Cartwright, G. Paterson, +11 authors M. Török
- Medicine, Biology
- Journal of Clinical Microbiology
- 29 May 2013
ABSTRACT The emergence of mecC methicillin-resistant Staphylococcus aureus (MRSA) poses a diagnostic challenge for clinical microbiology laboratories. Using the Vitek 2 system, we tested a panel of… Expand
Complex Routes of Nosocomial Vancomycin-Resistant Enterococcus faecium Transmission Revealed by Genome Sequencing
- K. Raven, T. Gouliouris, +7 authors S. Peacock
- Clinical infectious diseases : an official…
- 23 February 2017
Summary We generated genome sequence data from 293 Enterococcus faecium isolates from patients with bacteremia spanning 7 years in one hospital. Cases were connected to numerous transmission routes,… Expand
Impact of infectious diseases consultation on the management of Staphylococcus aureus bacteraemia in children
Objectives Infectious diseases consultation (IDC) in adults with Staphylococcus aureus bacteraemia (SAB) has been shown to improve management and outcome. The aim of this study was to evaluate the… Expand
The Protective Role of Albumin in Clostridium difficile Infection: A Step Toward Solving the Puzzle.
Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients
- Danesh Moradigaravand, T. Gouliouris, +7 authors S. Peacock
- Medicine, Biology
- Genome Medicine
- 27 December 2017
BackgroundEnterococcus faecium is a leading cause of hospital-acquired infection, particularly in the immunocompromised. Here, we use whole genome sequencing of E. faecium to study within-host… Expand