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The Continuing Challenges of Leprosy
This review focuses on recent advances in the understanding of M. leprae and the host response to it, especially concerning molecular identification of M.'s genome, transcriptome, and proteome, its mechanisms of microbial resistance, and recognition of strains by variable-number tandem repeat analysis.
Characterization of rifampin-resistance in pathogenic mycobacteria
Information served as the basis for developing a rapid DNA diagnostic assay (PCR-heteroduplex formation) for the detection of rifampin susceptibility of M. tuberculosis.
Contribution of rpoB Mutations to Development of Rifamycin Cross-Resistance in Mycobacterium tuberculosis
Results provided additional proof of the association of specificrpoB mutations with the development of rifamycin resistance and corroborate previous reports of the usefulness of rpoB genotyping for predicting r ifamycin-resistant phenotypes.
Probable zoonotic leprosy in the southern United States.
Wild armadillos and many patients with leprosy in the southern United States are infected with the same strain of M. leprae, andLeprosy may be a zoonosis in the region.
Development of leprosy and type 1 leprosy reactions after treatment with infliximab: a report of 2 cases.
The first 2 cases of leprosy developing after treatment with infliximab are reported, and both patients developed type 1 ("reversal") leproSy reactions.
Presence of F420-dependent glucose-6-phosphate dehydrogenase in Mycobacterium and Nocardia species, but absence from Streptomyces and Corynebacterium species and methanogenic Archaea.
A range of organisms known to contain F420 or to be relatives of mycobacteria were examined for F420-dependent glucose-6-phosphate dehydrogenase (FGD) and NADP-dependent glucose-6-phosphate
Dihydropteroate Synthase of Mycobacterium leprae and Dapsone Resistance
Results prove that the folP1 of M. leprae encodes a functional DHPS and that mutations within this gene are associated with the development of dapsone resistance in clinical isolates of M .
Mycobacterium leprae typing by genomic diversity and global distribution of genotypes.
The genetic diversity and related global distribution of 51 Mycobacterium leprae isolates were studied and obtained from leprosy patients from 12 geographically distinct regions of the world and two nonhuman sources revealed the latter genotype.
The Missing Millions: A Threat to the Elimination of Leprosy
Since 2000, the focus has moved from prevalence of leprosy to incidence as measured by reported new case detection to sustain the achievements and to reduce the burden of disease, particularly on reduction and prevention of disability associated with leproSy and rehabilitation of those facing the long-term consequences of the disease.
Transmission of leprosy: a study of skin and nasal secretions of household contacts of leprosy patients using PCR.
It is suggested that both skin and nasal epithelia of untreated MB leprosy patients contribute to the shedding of M. leprae into the environment and contacts of untreatedMB cases are at risk for contact with M.LePrae through both the nasal mucosa and exposed surfaces of their skin.