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Deletions in vaccine strains of pseudorabies virus and their effect on synthesis of glycoprotein gp63
The pseudorabies virus vaccine strains Norden and Bartha each have been reported to have deletions in the small unique component of the genome, but the deletion in Norden was shown to delete the entire coding region for gI but not any of the coding sequences for gp63. Expand
An ultra-high sulfur keratin gene is expressed specifically during hair growth.
- A. McNab, L. Wood, N. Theriault, T. Gierman, G. Vogeli
- Biology, Medicine
- The Journal of investigative dermatology
- 1 February 1989
RNA dot blots show that the ultra-high sulfur keratin gene is expressed during the hair cycle concomitant with the anterior-posterior temporal pattern of the normal murine hair cycle. Expand
Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription.
- Carol D. Laherty, T. Gierman, V. Dixit
- Medicine, Biology
- The Journal of biological chemistry
- 5 July 1989
Thrombospondin is an extracellular matrix glycoprotein whose synthesis and secretion by mesenchymal cells is regulated at the level of gene transcription by platelet-derived growth factor, and cis-acting regulatory sequences are found in the 5'-flanking sequence. Expand
Discovery and analysis of a novel parvovirus B19 Genotype 3 isolate in the United States
Parvovirus B19V Genotype 3 is a rarely occurring genotype that has been detected primarily in Ghana with sporadic reports in Brazil and France but has not been previously reported in North America. Expand
Ensuring the Biologic Safety of Plasma-Derived Therapeutic Proteins
Advances in science and pathogen safety-related technology, compliance with good manufacturing practices by manufacturers, and increasingly stringent regulatory oversight has meant that plasma-derived proteins have been developed into today’s highly effective therapeutics with very low risk of disease transmission. Expand
The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication.
The results suggest that vaccinia virus does not gain preferential translation of viral m RNAs over other mRNAs in the cell by reducing either eIF-4E phosphorylation or its ability to bind to the cap structure. Expand
Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling
This dataset provides the immunology community with a resource to compare and extract data from rigorously characterized healthy subjects across age groups, gender and race. Expand
ESTABLISHMENT OF THE FIRST NATIONAL STANDARD FOR NUCLEIC ACID AMPLIFICATION TECHNOLOGY ASSAY FOR HCV RNA
Technical considerations for the performance of Nucleic acid Amplification Technology (NAT). The NAT Task Force Group.
- M. Chudy, I. Hewlett, +10 authors G. Zerlauth
- Biology, Medicine
- Biologicals : journal of the International…
- 1 September 2003
Technical considerations for the performance of NAT include the collection, handling and assay of specimens and the design of laboratories to routinely and reliably detect low levels of nucleic acid sequences. Expand
Plasma Donors in the Southwestern United States Positively Contribute to the Diverse Therapeutic Antibody Profile of Immune Globulin Products
- Jonathan M Ciencewicki, Katherine R. Schouest, T. Gierman, P. Vandeberg, B. Gooch
- Scientific Reports
- 22 April 2020
Elevated anti-HAV Ig titers were broadly observed across plasma units obtained from the centers exhibiting high titers, indicative of a potential regional phenomenon among donors as opposed to few donors with singularly high titer. Expand