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Ebola haemorrhagic fever
TLDR
Ebola virus infections are characterised by immune suppression and a systemic inflammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock. Expand
Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
TLDR
Bystander lymphocyte apoptosis and loss of NK cells was a prominent finding, suggesting the importance of innate immunity in determining the fate of the host, and EBOV has evolved additional mechanisms to resist host defenses by inducing protective transcripts in cells that it infects. Expand
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
TLDR
The etymological derivation of individual names, their pronunciation, and their correct use are explained, and demarcation criteria for each taxon and virus are elaborate. Expand
A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever.
TLDR
Mice serially passed EBO-Z virus in progressively older suckling mice, eventually obtaining a plaque-purified virus that was lethal for mature, immunocompetent BALB/c and C57BL/6 inbred and ICR (CD-1) outbred mice. Expand
Lipid Raft Microdomains: A Gateway for Compartmentalized Trafficking of Ebola and
TLDR
The compartmentalization of Ebola and Marburg viral proteins within lipid rafts during viral assembly and budding is reported, suggesting that viral exit occurs at the rafts and that the entry of filoviruses requires functional rafts. Expand
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
TLDR
The data suggest that these replication-competent vaccines against EBOV and MARV based on attenuated recombinant vesicular stomatitis virus vectors are safe and highly efficacious in a relevant animal model. Expand
Preliminary report: isolation of Ebola virus from monkeys imported to USA
TLDR
This incident, the first in which a filovirus has been isolated from non-human primates without deliberate infection, raises the possibility that cynomolgus monkeys could be a reservoir of Ebola virus infection. Expand
Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells.
TLDR
Data suggest that coagulation abnormalities associated with EBOV HF are not the direct result of E BOV-induced cytolysis of endothelial cells, and are likely triggered by immune-mediated mechanisms. Expand
Exotic emerging viral diseases: progress and challenges
TLDR
Comparisons among VHFs show that a common pathogenic feature is their ability to disable the host immune response by attacking and manipulating cells that initiate the antiviral response, and highlight critical gaps in knowledge of these pathogens. Expand
Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event.
TLDR
It is reported that tissue factor (TF) plays an important role in triggering the hemorrhagic complications that characterize EBOV infections, and chemotherapeutic strategies aimed at controlling overexpression of TF may ameliorate the effects of E BOV hemorrhagic fever. Expand
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