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- Publications
- Influence
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function
- T. Geijtenbeek, S. V. van Vliet, +4 authors Y. van Kooyk
- Biology, Medicine
- The Journal of experimental medicine
- 6 January 2003
Mycobacterium tuberculosis represents a world-wide health risk and immunosuppression is a particular problem in M. tuberculosis infections. Although macrophages are primarily infected, dendritic… Expand
A promoter-level mammalian expression atlas
- The Fantom Consortium, Riken Pmii, +261 authors Y. Hayashizaki
- Biology, Computer Science
- Nature
- 27 March 2014
TLDR
C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB.
- S. Gringhuis, J. den Dunnen, M. Litjens, B. van het Hof, Y. van Kooyk, T. Geijtenbeek
- Medicine
- Immunity
- 2007
Adaptive immune responses by dendritic cells (DCs) are critically controlled by Toll-like receptor (TLR) function. Little is known about modulation of TLR-specific signaling by other pathogen… Expand
Innate signaling and regulation of Dendritic cell immunity.
- S. V. van Vliet, J. den Dunnen, S. Gringhuis, T. Geijtenbeek, Y. van Kooyk
- Biology, Medicine
- Current opinion in immunology
- 1 August 2007
Dendritic cells are crucial in pathogen recognition and induction of specific immune responses to eliminate pathogens from the infected host. Host recognition of invading microorganisms relies on… Expand
Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.
- T. Geijtenbeek, P. C. Groot, +6 authors Y. van Kooyk
- Biology, Medicine
- Blood
- 15 October 2002
Antigen-presenting cells are localized in essentially every tissue, where they operate at the interface of innate and acquired immunity by capturing pathogens and presenting pathogen-derived peptides… Expand
Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets
- C. M. Ribeiro, R. Sarrami-Forooshani, +7 authors T. Geijtenbeek
- Biology, Medicine
- Nature
- 15 December 2016
The most prevalent route of HIV-1 infection is across mucosal tissues after sexual contact. Langerhans cells (LCs) belong to the subset of dendritic cells (DCs) that line the mucosal epithelia of… Expand
FANTOM5 CAGE profiles of human and mouse samples
- S. Noguchi, T. Arakawa, +175 authors Y. Hayashizaki
- Biology, Medicine
- Scientific data
- 29 August 2017
In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE (Cap Analysis of… Expand
C-Type Lectin Receptors in Antiviral Immunity and Viral Escape
- Marta Bermejo-Jambrina, J. Eder, +4 authors T. Geijtenbeek
- Biology, Medicine
- Front. Immunol.
- 26 March 2018
C-type lectin receptors (CLRs) are important pattern recognition receptors involved in recognition and induction of adaptive immunity to pathogens. Certain CLRs play an important role in viral… Expand
Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.
- A. W. Mesman, Esther M. Zijlstra-Willems, +7 authors T. Geijtenbeek
- Biology, Medicine
- Cell host & microbe
- 9 July 2014
Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in viral dissemination. However, DCs express the RIG-I-like receptors (RLRs) RIG-I and Mda5 that sense MV and induce… Expand
Differences in Anti-Inflammatory Actions of Intravenous Immunoglobulin between Mice and Men: More than Meets the Eye
- A. Tjon, R. van Gent, T. Geijtenbeek, J. Kwekkeboom
- Medicine
- Front. Immunol.
- 28 April 2015
Intravenous immunoglobulin (IVIg) is a therapeutic preparation of polyspecific human IgGs purified from plasma pooled from thousands of individuals. When administered at a high dose, IVIg inhibits… Expand