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Haemonchus contortus: ivermectin-induced paralysis of the pharynx.
The data suggest that H. contortus depends upon the transcuticular uptake of glucose in culture and disruption of this process may represent the primary mechanism of IVM action, which is essential for long-term survival in vivo.
Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.
Ivermectin 20 years on: maturation of a wonder drug.
- T. Geary
- BiologyTrends in Parasitology
- 1 November 2005
Haemonchus contortus: sequence heterogeneity of internucleotide binding domains from P-glycoproteins.
- N. Sangster, S. Bannan, A. Weiss, S. C. Nulf, R. Klein, T. Geary
- BiologyExperimental parasitology
- 1 March 1999
Northern blotting showed that P-glycoprotein genes are transcribed in a developmentally regulated fashion in Haemonchus contortus, and a pattern consistent with the involvement of P- glycoprotein in resistance to avermectin/milbemycin anthelmintics was revealed.
Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi
- Yovany Moreno, J. Nabhan, J. Solomon, C. Mackenzie, T. Geary
- BiologyProceedings of the National Academy of Sciences
- 1 November 2010
Results show that IVM treatment of microfilariae results in a marked reduction of protein release from the ES apparatus, which is proposed to result from suppression of the ability of the parasite to secrete proteins that enable evasion of the host immune system.
Anthelmintic Drug Discovery: Into the Future
The approaches and technologies in use to identify anthelmintics are reviewed and a number of drug discovery paradigms that may prove pivotal to the next half-century of anthel Mintic development are discussed.
Unresolved issues in anthelmintic pharmacology for helminthiases of humans.
Stage- and Gender-Specific Proteomic Analysis of Brugia malayi Excretory-Secretory Products
A comparative analysis of the proteins released in vitro by different forms of a parasitic nematode dwelling in the same host is presented, providing valuable insights on the contribution of each form of the parasite for establishing the host–parasite interaction.
The FLP-side of nematodes.
Nutritional requirements of Plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth.
Continuous cultivation of Plasmodium falciparum presently requires the nutritionally complex medium, RPMI 1640. A basal medium of KCl, NaCl, Na2HPO4, Ca(NO3)2, MgSO4, glucose, reduced glutathione,…