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Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion.
We studied the effects of exogenous nitric oxide (NO) on leukocyte-endothelial interaction after 60 min of splanchnic artery ischemia and 120 min of reperfusion (SAO/R) in pentobarbitalExpand
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Nitric oxide protects against leukocyte-endothelium interactions in the early stages of hypercholesterolemia.
We studied the effects of CAS1609, a nitric oxide donor, on leukocyte-endothelial interactions during the early stages of hypercholesterolemia in rat mesenteric microcirculation. Rats were randomlyExpand
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Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?
Although pulmonary function is not altered, a history of alcohol abuse is an independent outcome variable in the development of acute respiratory distress syndrome. In the absence of cirrhosis,Expand
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Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation.
BACKGROUND/AIMS Inhibition of nitric oxide synthesis increases leukocyte and endothelial interaction in mesenteric venules. In this study, the relationship between inhibition of NO and expression ofExpand
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Association of Glutathione-S-Transferase-P1 (GST-P1) Polymorphisms with Bronchopulmonary Dysplasia
OBJECTIVE: Reactive oxygen species (ROS) contribute to oxidative lung injury. The glutathione-S-transferases (GST) family and microsomal epoxide hydrolase (mEPHx) enzymes detoxify ROS, and geneticExpand
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Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.
We have previously demonstrated that chronic alcohol exposure decreases glutathione in the alveolar space. Although alcohol use is associated with decreased alveolar macrophage function, theExpand
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Maternal alcohol abuse and neonatal infection.
BACKGROUND Since chronic alcohol use suppresses the adult immune system, we tested the hypothesis that maternal alcohol ingestion increases the risk of infection in term newborns. METHODS AnalysisExpand
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Fetal Alcohol Exposure Impairs Alveolar Macrophage Function via Decreased Glutathione Availability
Immature function of the alveolar macrophage increases the risk of pulmonary infections in premature newborns. In utero alcohol increases fetal systemic oxidative stress. Because the premature lungExpand
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In vivo dysfunction of the term alveolar macrophage after in utero ethanol exposure.
BACKGROUND The effects of in utero alcohol exposure on the immune function of the newborn remain under investigation. Fetal ethanol (ETOH) exposure increases oxidative stress in the developing lung,Expand
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Prenatal Alcohol Exposure and the Developing Immune System
  • T. Gauthier
  • Biology, Medicine
  • Alcohol research : current reviews
  • 2015
Evidence from research in humans and animals suggest that ingesting alcohol during pregnancy can disrupt the fetal immune system and result in an increased risk of infections and disease in newbornsExpand
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