Optimization of molecular design in the evolution of metabolism: the glycogen molecule.
- E. Meléndez-Hevia, T. G. Waddell, E. D. Shelton
- BiologyBiochemical Journal
- 15 October 1993
The results demonstrate that the structure of the glycogen molecule is optimized to maximize the total glucose stored in the smallest possible volume, the proportion of it that can be directly released by phosphorylase before any debranching occurs, and the number of non-reducing ends, which maximizes the speed of fuel release.
The puzzle of the Krebs citric acid cycle: Assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways during evolution
- E. Meléndez-Hevia, T. G. Waddell, M. Cascante
- BiologyJournal of Molecular Evolution
- 1 September 1996
Analysis of the Krebs cycle as a problem of chemical design to oxidize acetate yielding reduction equivalents to the respiratory chain to make ATP demonstrates that although there are several different chemical solutions to this problem, the design of this metabolic pathway as it occurs in living cells is the best chemical solution.
The nature of organosilane to silica-surface bonding
- T. G. Waddell, D. Leyden, M. DeBello
- Chemistry
- 1 September 1981
Mode of action of sesquiterpene lactones as anti-inflammatory agents.
- I. Hall, C. Starnes, K. Lee, T. G. Waddell
- Chemistry, BiologyJournal of Pharmacy and Science
- 1 May 1980
The structure-activity relationships for the stabilization of lysosomal membrane for rat liver cathepsin activity followed the same structural requirement necessary for anti-inflammatory activity; i.e., the alpha-methylene-gamma-lactone moiety contributed the most activity, whereas the beta-unsubstituted cyclopentenone and alpha-epoxycyclopentanone contributed only minor activity.
Theoretical approaches to the evolutionary optimization of glycolysis: thermodynamic and kinetic constraints.
- Reinhart Heinrich, F. Montero, E. Klipp, T. G. Waddell, E. Meléndez-Hevia
- BiologyEuropean Journal of Biochemistry
- 1997
The mathematical analysis of a minimal model of unbranched energy-converting pathways shows that the requirement of high ATP-production rate favours a structural design that includes not only ATP-producing reactions but also ATP-consuming reactions (C-sites).
Optimization of Metabolism: The Evolution of Metabolic Pathways Toward Simplicity Through the Game of the Pentose Phosphate Cycle
- E. Meléndez-Hevia, T. G. Waddell, F. Montero
- Biology
- 21 January 1994
The results demonstrate that both the design of this pathway and the enzyme mechanisms themselves have been optimized, and it is not possible to find any other set of enzyme mechanisms capable of producing a simpler solution for the pentose phosphate pathway.
Optimization of Glycolysis: A New Look at the Efficiency of Energy Coupling
- T. G. Waddell, P. Repovic, E. Meléndez-Hevia, R. Heinrich, F. Montero
- Biology
- 1 October 1997
Optimization of glycolysis: new discussions
- T. G. Waddell, P. Repovic, E. Meléndez-Hevia, R. Heinrich, F. Montero
- Biology
- 1999
Advanced Organic Chemistry, 4th Edition. Part B: Reactions and Synthesis (Book)
- T. G. Waddell
- Chemistry
- 2003
Antitumor agents. 21. A proposed mechanism for inhibition of cancer growth by tenulin and helenalin and related cyclopentenones.
- I. Hall, K. Lee, E. Mar, C. Starnes, T. G. Waddell
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1 March 1977
Evidence is presented that sesquiterpene lactones or ketones containing the O=CC=CH2 moiety alkylate the thiol group of reduced glutathione and L-cysteine in vitro, and it is thought that this mechanism of action is responsible for the observed potent in vivo antitumor activity of these agents in the Ehrlich ascites and Walker 256 carcinosarcoma and to a lesser extent in the P388 leukemic screen.
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