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Optimization of molecular design in the evolution of metabolism: the glycogen molecule.
The animal glycogen molecule has to be designed in accordance with its metabolic function as a very effective fuel store allowing quick release of large amounts of glucose. In addition, the designExpand
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The puzzle of the Krebs citric acid cycle: Assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways during evolution
The evolutionary origin of the Krebs citric acid cycle has been for a long time a model case in the understanding of the origin and evolution of metabolic pathways: How can the emergence of such aExpand
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Optimization of Metabolism: The Evolution of Metabolic Pathways Toward Simplicity Through the Game of the Pentose Phosphate Cycle
Abstract Previous theoretical studies on the pentose phosphate cycle (Melendez-Hevia et al., 1985, 1988, 1990) demonstrated that simplicity in metabolism, defined as the least possible number ofExpand
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Optimization of Glycolysis: A New Look at the Efficiency of Energy Coupling
Introduction: the efficiency of glycolysis The pathway of carbohydrate metabolism called glycolysis serves to provide cells with energy in the form of adeno- sine triphosphate (ATP) under anaerobicExpand
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Optimization of glycolysis: new discussions
The concept of glycolysis optimization, first presented in Waddell (Biochemical Education 25 (1997) 204–205) and Heinrich et al. (Eur. J. Biochem. 243 (1997) 191–201), is reiterated and clarified inExpand
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Mode of action of sesquiterpene lactones as anti-inflammatory agents.
Sesquiterpene lactones containing an alpha-methylene-gamma-lactone moiety were shown to be potent inhibitors of carrageenan-induced edema and chronic adjuvant-induced arthritis in rodents at 2.5Expand
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Theoretical approaches to the evolutionary optimization of glycolysis--chemical analysis.
In the first part of this work [Heinrich, R., Montero, F., Klipp, E., Waddell, T. G. & Melendez-Hevia, E. (1997) Eur. J. Biochem. 243, 191-201] the kinetic and thermodynamic constraints under whichExpand
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Theoretical approaches to the evolutionary optimization of glycolysis: thermodynamic and kinetic constraints.
It is analyzed whether the structural design of contemporary glycolysis can be explained theoretically on the basis of optimization principles originating from natural selection during evolution.Expand
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