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Optimization of molecular design in the evolution of metabolism: the glycogen molecule.
The results demonstrate that the structure of the glycogen molecule is optimized to maximize the total glucose stored in the smallest possible volume, the proportion of it that can be directly released by phosphorylase before any debranching occurs, and the number of non-reducing ends, which maximizes the speed of fuel release. Expand
The puzzle of the Krebs citric acid cycle: Assembling the pieces of chemically feasible reactions, and opportunism in the design of metabolic pathways during evolution
Analysis of the Krebs cycle as a problem of chemical design to oxidize acetate yielding reduction equivalents to the respiratory chain to make ATP demonstrates that although there are several different chemical solutions to this problem, the design of this metabolic pathway as it occurs in living cells is the best chemical solution. Expand
Optimization of Metabolism: The Evolution of Metabolic Pathways Toward Simplicity Through the Game of the Pentose Phosphate Cycle
The results demonstrate that both the design of this pathway and the enzyme mechanisms themselves have been optimized, and it is not possible to find any other set of enzyme mechanisms capable of producing a simpler solution for the pentose phosphate pathway. Expand
Mode of action of sesquiterpene lactones as anti-inflammatory agents.
The structure-activity relationships for the stabilization of lysosomal membrane for rat liver cathepsin activity followed the same structural requirement necessary for anti-inflammatory activity; i.e., the alpha-methylene-gamma-lactone moiety contributed the most activity, whereas the beta-unsubstituted cyclopentenone and alpha-epoxycyclopentanone contributed only minor activity. Expand
Theoretical approaches to the evolutionary optimization of glycolysis: thermodynamic and kinetic constraints.
The mathematical analysis of a minimal model of unbranched energy-converting pathways shows that the requirement of high ATP-production rate favours a structural design that includes not only ATP-producing reactions but also ATP-consuming reactions (C-sites). Expand
Optimization of Glycolysis: A New Look at the Efficiency of Energy Coupling
The efficiency of glycolysis is studied to provide cells with energy in the form of adeno- sine triphosphate (ATP) under anaerobic conditions. Expand
Optimization of glycolysis: new discussions
The concept of glycolysis optimization, first presented in Waddell (Biochemical Education 25 (1997) 204–205) and Heinrich et al. (Eur. J. Biochem. 243 (1997) 191–201), is reiterated and clarified inExpand
Circular dichroism and optical rotatory dispersion of sesquiterpene lactones
Abstract The CD curves of a large number of sesquiterpene lactones together with a limited number of ORD curves have been measured. A simple correlation between the sign of the Cotton effect (CE) andExpand