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The human side of hypoxia-inducible factor
When humans are exposed to hypoxia, systemic and intracellular changes operate together to minimise hypoxic injury and restore adequate oxygenation. Emerging evidence indicates that theExpand
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Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
BACKGROUND The von Hippel-Lindau tumour suppressor protein-hypoxia-inducible factor (VHL-HIF) pathway has attracted widespread medical interest as a transcriptional system controlling cellularExpand
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Regulation of human metabolism by hypoxia-inducible factor
The hypoxia-inducible factor (HIF) family of transcription factors directs a coordinated cellular response to hypoxia that includes the transcriptional regulation of a number of metabolic enzymes.Expand
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Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials.
CONTEXT Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at high altitude. Recent work has established that the effect of hypoxia on pulmonary arterial pressure mayExpand
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Therapeutic manipulation of the HIF hydroxylases.
The hypoxia-inducible factor (HIF) family of transcription factors is responsible for coordinating the cellular response to low oxygen levels in animals. By regulating the expression of a large arrayExpand
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Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation
The hypoxia‐inducible factors (HIFs; isoforms HIF‐1α, HIF‐2α, HIF‐3α) mediate many responses to hypoxia. Their regulation is principally by oxygen‐dependent degradation, which is initiated byExpand
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Regulation of hepcidin expression at high altitude.
Enhanced erythropoietic drive and iron deficiency both influence iron homeostasis through the suppression of the iron regulatory hormone hepcidin. Hypoxia also suppresses hepcidin through a mechanismExpand
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The increase in pulmonary arterial pressure caused by hypoxia depends on iron status
Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia‐inducible factor (HIF) is central to this process. The oxygen‐sensing iron‐dependentExpand
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Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
•  Arterial hypoxaemia leads to a rapid increase in ventilation. If the hypoxaemia is sustained, a further increase in ventilation develops over hours to days in a process termed ventilatoryExpand
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Pulmonary artery pressure increases during commercial air travel in healthy passengers.
BACKGROUND It is not known whether the mild hypoxia experienced by passengers during commercial air travel triggers hypoxic pulmonary vasoconstriction and increases pulmonary artery pressure inExpand
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