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Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors.
  • A. Dace, L. Zhao, +6 authors S. Cheng
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 2000
TLDR
A role of T3 is revealed in modulating the functions of TR by regulating its receptor level via the ubiquitin-proteasome degradation pathway. Expand
Direct neurite-mast cell communication in vitro occurs via the neuropeptide substance P.
TLDR
It is illustrated that nerve-mast cell cross-talk can occur in the absence of an intermediary transducing cell and that the neuropeptide substance P, operating via NK-1 receptors, is an important mediator of this communication. Expand
Membrane fusion plays an important role in gene transfection mediated by cationic liposomes
TLDR
The results suggest that at least two steps are effective for gene transfection mediated by the cationic liposomes with cATIONic cholesterol derivatives, including the endocytosis of the liposome/DNA complex into the target cells and the removal of antisense oligonucleotides (plasmid DNAs) from the complex in the endosomes. Expand
Atomic force microscopy for studying gene transfection mediated by cationic liposomes with a cationic cholesterol derivative
TLDR
From the results it was found that the vesicles with moderate diameters were moste effective for gene transfection of plasmid pSV2CAT DNA into the target cell. Expand
Effect of NeuroD2 expression on neuronal differentiation in mouse embryonic stem cells
TLDR
The results suggest that the expression of NeuroD2 requires an appropriate period of about 3 days to elicit neuronal differentiation in ES cells. Expand
Neurotrophic factors increase tumor necrosis factor-alpha-induced nuclear translocation of NF-kappaB in rat PC12 cells.
TLDR
There is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation, and that NGF and BDNF enhance TNF-alpha-induced nuclear translocation of NF- kappaB. Expand
Surface expression of CD63 antigen (AD1 antigen) in P815 mastocytoma cells by transfected IgE receptors.
TLDR
The results suggested that tyrosine phosphorylation of the C-terminal cytoplasmic domains of beta and gamma subunits was essential for degranulation in rat basophilic leukemia cells. Expand
Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells.
TLDR
Analysis of the movement of each granule provided a new insight into the elementary process of degranulation and showed that the granules are able to reach the plasma membranes in 2 or 3 min if the diameter of the cells is 20 microm. Expand
Neurotrophic factors increase tumor necrosis factor-α-induced nuclear translocation of NF-κB in rat PC12 cells
TLDR
There is a close correlation between the signaling pathways via TNF receptors and neurotrophin receptors for the NF-kappaB activation, and that NGF and BDNF enhance TNF-alpha-induced nuclear translocation of NF- kappaB. Expand
Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation
TLDR
Both MCU and MICU1 are involved in mitochondrial Ca2+ uptake in mast cells, while MCU plays a role in mast cell degranulation, according to microscopic analysis at the single-cell level. Expand
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