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Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
- S. Chaki, T. Funakoshi, W. Thomsen
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 May 2005
Findings indicate that ATC0065 and ATC0175 are potent and orally active MCHR1 antagonists with anxiolytic and antidepressant activity in rodents.
Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors.
Involvement of the melanocortin MC4 receptor in stress-related behavior in rodents.
Role of 5-HT1A Receptor Stimulation in the Medial Prefrontal Cortex in the Sustained Antidepressant Effects of Ketamine
- K. Fukumoto, M. Iijima, T. Funakoshi, S. Chaki
- Biology, PsychologyThe international journal of…
- 22 December 2017
Results indicate that selective stimulation of the medial prefrontal cortex serotonin1A receptor and subsequent activation of the phosphoinositide-3 kinase/Akt/mechanistic target of rapamycin complex-1 pathway may be necessary for ketamine to exert the sustained antidepressant effects, and that this mechanism could be targeted to develop a novel and effective approach for treating depression.
Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent…
- S. Chaki, Shiho Hirota, S. Okuyama
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 February 2003
Observations indicate that MCL0129 is a potent and selective MC4 antagonist with anxiolytic- and antidepressant-like activities in various rodent models.
MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity
A selective dopamine D4 receptor antagonist, NRA0160: a preclinical neuropharmacological profile.
5-HT1A receptor stimulation in the medial prefrontal cortex mediates the antidepressant effects of mGlu2/3 receptor antagonist in mice
Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1.