• Publications
  • Influence
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K., et al., Biochem. Biophys. Res. Commun. 221, 286-289, 1996). The apM1 gene product was a kind of solubleExpand
  • 4,499
  • 160
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceralExpand
  • 1,249
  • 150
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body massExpand
  • 3,028
  • 104
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
Plasma concentrations of adiponectin, a novel adipose-specific protein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity,Expand
  • 3,336
  • 98
  • PDF
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic properties,Expand
  • 1,619
  • 50
  • PDF
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice. Adiponectin/ACRP30-knockout (KO) mice showed delayedExpand
  • 1,982
  • 46
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
Obesity-related disorders are associated with the development of ischemic heart disease. Adiponectin is a circulating adipose-derived cytokine that is downregulated in obese individuals and afterExpand
  • 870
  • 40
Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-&kgr;B Signaling Through a cAMP-Dependent Pathway
BackgroundAmong the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectinExpand
  • 1,607
  • 28
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors.
Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and atherosclerosis.Expand
  • 693
  • 27
  • PDF
Adiponectin-mediated modulation of hypertrophic signals in the heart
Patients with diabetes and other obesity-linked conditions have increased susceptibility to cardiovascular disorders. The adipocytokine adiponectin is decreased in patients with obesity-linkedExpand
  • 603
  • 26