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Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
- Y. Arita, S. Kihara, +16 authors Y. Matsuzawa
- Medicine, Biology
- Biochemical and biophysical research…
- 2 April 1999
We isolated the human adipose-specific and most abundant gene transcript, apM1 (Maeda, K., et al., Biochem. Biophys. Res. Commun. 221, 286-289, 1996). The apM1 gene product was a kind of soluble… Expand
Visfatin: a protein secreted by visceral fat that mimics the effects of insulin.
Fat tissue produces a variety of secreted proteins (adipocytokines) with important roles in metabolism. We isolated a newly identified adipocytokine, visfatin, that is highly enriched in the visceral… Expand
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
- K. Hotta, T. Funahashi, +18 authors Y. Matsuzawa
- Medicine, Biology
- Arteriosclerosis, thrombosis, and vascular…
- 1 June 2000
Adiponectin is a novel, adipose-specific protein abundantly present in the circulation, and it has antiatherogenic properties. We analyzed the plasma adiponectin concentrations in age- and body mass… Expand
Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.
- C. Weyer, T. Funahashi, +4 authors P. A. Tataranni
- The Journal of clinical endocrinology and…
- 1 May 2001
Plasma concentrations of adiponectin, a novel adipose-specific protein with putative antiatherogenic and antiinflammatory effects, were found to be decreased in Japanese individuals with obesity,… Expand
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.
Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic properties,… Expand
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Here we investigated the biological functions of adiponectin/ACRP30, a fat-derived hormone, by disrupting the gene that encodes it in mice. Adiponectin/ACRP30-knockout (KO) mice showed delayed… Expand
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
Obesity-related disorders are associated with the development of ischemic heart disease. Adiponectin is a circulating adipose-derived cytokine that is downregulated in obese individuals and after… Expand
Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-&kgr;B Signaling Through a cAMP-Dependent Pathway
BackgroundAmong the many adipocyte-derived endocrine factors, we found an adipocyte-derived plasma protein, adiponectin, that was decreased in obesity. We recently demonstrated that adiponectin… Expand
Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors.
Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and atherosclerosis.… Expand
Adiponectin-mediated modulation of hypertrophic signals in the heart
Patients with diabetes and other obesity-linked conditions have increased susceptibility to cardiovascular disorders. The adipocytokine adiponectin is decreased in patients with obesity-linked… Expand