Share This Author
C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)*
- Y. Morohashi, T. Kan, T. Tomita
- Chemistry, BiologyJournal of Biological Chemistry
- 26 May 2006
TLDR
Activity-Dependent Proteolytic Cleavage of Neuroligin-1
- Kunimichi Suzuki, Y. Hayashi, T. Iwatsubo
- BiologyNeuron
- 18 October 2012
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
- T. Tomita, N. Takasugi, T. Iwatsubo
- Biology, ChemistryAlzheimer's & Dementia
- 4 May 2011
TLDR
Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation*
- Yasuko Takahashi, I. Hayashi, T. Iwatsubo
- Biology, ChemistryThe Journal of Biological Chemistry
- 16 May 2003
TLDR
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.
- Yasuko Takahashi, I. Hayashi, T. Iwatsubo
- BiologyThe Journal of biological chemistry
- 2003
TLDR
Total synthesis of ecteinascidin 743.
- A. Endo, A. Yanagisawa, Masanao Abe, S. Tohma, T. Kan, T. Fukuyama
- ChemistryJournal of the American Chemical Society
- 17 May 2002
The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde…
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
- T. Miyagawa, Ihori Ebinuma, T. Tomita
- Biology, ChemistryHuman molecular genetics
- 14 May 2016
TLDR
Phenylpiperidine‐type γ‐secretase modulators target the transmembrane domain 1 of presenilin 1
- Y. Ohki, Takuya Higo, T. Iwatsubo
- Biology, ChemistryThe EMBO journal
- 30 November 2011
TLDR
Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors.
- H. Fuwa, Yasuko Takahashi, T. Iwatsubo
- Chemistry, BiologyACS chemical biology
- 25 May 2007
TLDR
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator
- Koji Takeo, S. Tanimura, T. Iwatsubo
- Chemistry, BiologyProceedings of the National Academy of Sciences
- 9 July 2014
TLDR
...
...