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BMP type I receptor inhibition reduces heterotopic ossification
The role of dysregulated ALK2 kinase activity in the pathogenesis of FOP is supported and small molecule inhibition of BMP type I receptor activity may be useful in treating FOP and heterotopic ossification syndromes associated with excessive BMP signaling.
Bone Morphogenetic Protein Type IA Receptor Signaling Regulates Postnatal Osteoblast Function and Bone Remodeling*
Bone morphogenetic proteins (BMPs) function during various aspects of embryonic development including skeletogenesis. However, their biological functions after birth are less understood. To…
Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells
The findings in the HMEC model suggested that the genetic and epigenetic alterations by BPA might damage HMEC function and result in complex activities related to cell proliferation and senescence, playing a role in mammary carcinogenesis.
Augmentation of smad‐dependent BMP signaling in neural crest cells causes craniosynostosis in mice
It is shown that enhanced bone morphogenetic protein (BMP) signaling through the BMP type IA receptor (BMPR1A) in cranial neural crest cells, but not in osteoblasts, causes premature suture fusion in mice, suggesting an important contribution of dysregulated BMP signaling to syndromic craniosynostoses and potential strategies for early intervention.
Effect of dietary addition of seaweed and licorice on the immune performance of pigs.
- M. Katayama, T. Fukuda, Keiichi Suzuki
- Biology, MedicineAnimal science journal = Nihon chikusan Gakkaiho
- 1 April 2011
It is concluded that the replacement of antibiotics by naturally derived dietary additives might be feasible for immune system enhancement in swine.
The Anti-Proliferative Effects of the CHFR Depend on the Forkhead Associated Domain, but not E3 Ligase Activity Mediated by Ring Finger Domain
It is confirmed that the FHA domain of CHFR protein is critical for growth suppressive properties, whereas the RF and cysteine rich domains (Cys) are not required for this function.
Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2
The conditional overexpression system described here provides versatility in investigating gene functions in a tissue‐specific manner without having to generate independent tissue‐ specific transgenic lines.
Distribution of Artificial Radionuclides in Abandoned Cattle in the Evacuation Zone of the Fukushima Daiichi Nuclear Power Plant
This study is the first to reveal the detailed systemic distribution of radionuclides in cattle attributed to the FNPP accident, and radiocesium activity concentration in organs was found to be dependent on the feeding conditions and the geographic location of the cattle.
Anti-proliferative effect of an analogue of the LL-37 peptide in the colon cancer derived cell line HCT116 p53+/+ and p53-/-.
The results indicate that the treatment of certain types of cancer cells with FF/CAP18 may increase the sensitivity of the chemotherapeutic reagents, which might relate to the reduction of the side-effects of the chemotherapy reagents.
Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells
This study showed that CSA-13 exerts an antiproliferative effect in cancer cells similar to that of FF/CAP-18, suggesting that membrane-permeabilizing capability is the common underlying mechanism for anticancer and antimicrobial effects of C SA-13 and anitimicrobial peptides.