• Publications
  • Influence
Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells.
AIMS: To assess the effects of the cytokines, interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1ra), transforming growth factor-beta 2 (TGF-beta 2) and basic fibroblast growth factor (b-FGF), onExpand
  • 98
  • 3
  • PDF
Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells.
Replication-competent oncolytic viruses are being developed for human cancer therapy. We previously reported that an attenuated adenovirus OBP-301 (Telomelysin), in which the human telomerase reverseExpand
  • 74
  • 3
In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus
Currently available methods for detection of tumors in vivo such as computed tomography and magnetic resonance imaging are not specific for tumors. Here we describe a new approach for visualizingExpand
  • 147
  • 2
  • PDF
Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by
BACKGROUND During perioperative management of patients with gastrointestinal cancer complicated by diabetes mellitus, adequate alimentation is required, but we often face difficulties associated withExpand
  • 5
  • 1
Enhanced antitumor efficacy of telomerase‐selective oncolytic adenoviral agent OBP‐401 with docetaxel: Preclinical evaluation of chemovirotherapy
Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase‐specific replication‐competentExpand
  • 41
Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery.
The inability to repair DNA double-strand breaks (DSB) leads to radiosensitization, such that ionizing radiation combined with molecular inhibition of cellular DSB processing may greatly affectExpand
  • 42
  • PDF
Combination of oncolytic adenovirotherapy and Bax gene therapy in human cancer xenografted models. Potential merits and hurdles for combination therapy
Cancer gene therapy and oncolytic virotherapy have been studied extensively. However, their clinical application is hampered by their weak anticancer activity. We previously constructed a replicatingExpand
  • 15
Cancer esearch apeutics , Targets , and Chemical Biology merase-Dependent Oncolytic Adenovirus Sensitizes an Cancer Cells to Ionizing Radiation via R bition of DNA Repair Machinery
Downloa inability to repair DNA double-strand breaks (DSB) leads to radiosensitization, such that ionizing racombined with molecular inhibition of cellular DSB processing may greatly affect treatmentExpand
  • 2
  • PDF
Near-bottom Magnetic Measurements with Submersible Shinkai 6500
海底に近い場所で地磁気を測ると, 高分解能地磁気異常が得られ, 海洋地殻の詳細な磁化構造や, 海洋地殻に記された古地磁気変動を調べることに役立つ. 潜水調査船を利用した地磁気調査では, 磁力計のシステムが簡便である, 海底の画像や採取試料等の他の観測情報が同時に入手できる等の長所がある. 潜水船は海底直上を移動できるので, 数mの分解能が期待できる.Expand