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Evidence for p53-Mediated Modulation of Neuronal Viability
A direct relationship between p53 expression and loss of viability in CNS neurons is demonstrated using adenovirus-mediated transduction to promote neuronal cell death even in the absence of excitotoxin. Expand
Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers
Direct administration of Telomelysin was proved to effectively eradicate solid tumors in vivo, without apparent adverse effects, and novel tools for cancer diagnostics and therapeutics were found by utilizing the hTERT promoter. Expand
Down‐regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1‐dependent DNA‐damage checkpoint signals contributes to cell cycle arrest at G1/S transition
  • Y. Arima, T. Hirota, +5 authors H. Saya
  • Biology, Medicine
  • Genes to cells : devoted to molecular & cellular…
  • 1 February 2004
It is demonstrated that ICBP90 expression is down‐regulated by the p53/p21Cip1/WAF1‐dependent DNA damage checkpoint signals, an important mechanism for cell cycle arrest at G1/S transition, which is induced by the activation of a p53 / p21 cip1 / WAF1 •dependent DNA‐damage checkpoint. Expand
Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells
The data indicate that p53-mediated downregulation of FLIP may explain the potent sensitization of human cancer cells to the apoptotic suicide program induced by wild-type p53 gene transfer. Expand
Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer
Overexpression of ciRS-7 in HCT116 and HT29 cells led to the blocking of miR-7 and resulted in a more aggressive oncogenic phenotype, and ci RS-7 overexpression permitted the inhibition of mi R7 and subsequent activation of EGFR and RAF1 oncogenes. Expand
Thoracic tumors treated with CT-guided radiofrequency ablation: initial experience.
RF ablation seems to be a promising treatment for malignant thoracic tumors, and local recurrence was demonstrated histopathologically or radiologically in nine tumors. Expand
Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria
The RIFLE criteria offer a useful predictive tool after LDLT and could have negative prognostic impact in the acute and late postoperative phases, and perioperative treatment strategies should be designed based on the risk factors for the further improvement of transplant prognosis. Expand
A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors.
Evidence of antitumor activity was suggested and Telomelysin was well tolerated at all dose levels, and seven patients fulfilled Response Evaluation Criteria in Solid Tumors (RECIST) definition for stable disease at day 56 after treatment. Expand
Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria*
It is shown that inhibition of RNA polymerase II-mediated transcription by α-amanitin or RNA interference induced p53-dependent apoptosis and was the critical factor for eliciting p 53-dependent but transcription-independent apoptosis. Expand
A novel human nucleoside diphosphate (NDP) kinase, Nm23‐H6, localizes in mitochondria and affects cytokinesis
Observations suggest that Nm23‐H6, a new member of the NDP kinase family, resides in mitochondria and plays a role in regulation of cell growth and cell cycle progression. Expand