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RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial
TLDR
Given that RNA helicase encoded by MDA-5 is a critical molecule involved in the innate immune defense against viruses, viral infection may play an important role in the pathogenesis of C-ADM and rapidly progressive ILD.
Prognostic Significance of Interleukin-8 and CD163-Positive Cell-Infiltration in Tumor Tissues in Patients with Oral Squamous Cell Carcinoma
TLDR
Findings indicate that IL-8 may be involved in poor clinical outcomes via generation of CD163-positive M2 macrophages from peripheral blood monocytes and that these factors in addition to N status may have prognostic value in patients with resectable OSCSS.
Systematic Identification of Human Melanoma Antigens Using Serial Analysis of Gene Expression (SAGE)
TLDR
A system using SAGE and immunoscreening with patients' sera is shown to be an efficient method for the systematic identification of tumor antigens and two melanocyte/melanoma-specific molecules are reported, which may be useful for development of diagnosis or treatment of these pigment disorders.
A Novel Cancer Testis Antigen That Is Frequently Expressed in Pancreatic, Lung, and Endometrial Cancers
TLDR
KU-CT-1 is a new cancer testis antigen that is expressed in pancreatic, lung, and endometrial cancers and may be useful for diagnosis and immunotherapy for patients with various cancers.
Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability.
TLDR
T tumor-specific peptides generated by MSI may be involved in antitumor immune responses and may be useful for the development of diagnostic and therapeutic methods for patients with MSI+ CRC.
Antitumor activity of new antitumor substance, polyoxomolybdate, against several human cancers in athymic nude mice.
TLDR
The growth suppressions of PM-8 against Co-4 human colon cancer xenografted under the subrenal capsule in cd-1 mice were equal or superior to that of 5-FU, MMC, ACNU, ADM and CDDP.
Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer
TLDR
WT1 peptide‐pulsed DCGEM is feasible and effective for inducing anti‐tumor T‐cell responses and support future investigations for pancreatic cancer patients with non‐liver metastases and favorable immunological conditions.
Identification of human tumor antigens and its implications for diagnosis and treatment of cancer
TLDR
The existence of immunogenic unique antigens derived from genetic alterations in tumor cells, and the varied immunogenicity of shared tumor antIGens among patients due to differing expression in tumors and immunore‐activity of patients, indicates that individualized immunotherapy should ideally be performed.
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