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Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians
TLDR
FTO is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans.
Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population
TLDR
The strength of association was more prominent in the Japanese population than in Europeans for more than half of the confirmed type 2 diabetes loci and significant associations were replicated in five other candidate loci.
Meta-analysis of the association of Trp64Arg polymorphism of beta 3-adrenergic receptor gene with body mass index.
TLDR
The hypothesis that the Trp64Arg polymorphism is associated with BMI across diverse population groups is supported, suggesting that the beta 3-adrenergic receptor gene locus plays a role in genetic predisposition to increased body weight in a universal manner.
A Polymorphism Regulates CYP4A11 Transcriptional Activity and Is Associated With Hypertension in a Japanese Population
TLDR
A functional variant (−845A/G) of CYP4A11 that is significantly associated with hypertension and that appears to be a novel candidate for a predisposing factor for hypertension is identified.
Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes.
TLDR
Data indicate that the contribution of HLA haplotypes to the genetic susceptibility to type 1 diabetes differs depending on the genotypic combination of DQB1-DQB1 haplotypes, suggesting the importance of extensive analysis of genotypes in studies on HLA and disease association in general.
Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy
TLDR
The data suggest that the ACE I/D polymorphism affects the risk for diabetic nephropathy, but not for diabetic retinopathy.
Prevention and Treatment of Obesity, Insulin Resistance, and Diabetes by Bile Acid–Binding Resin
TLDR
The molecular basis for a link between bile acids and glucose metabolism is provided and the bile acid metabolism pathway is suggested as a novel therapeutic target for the treatment of obesity, insulin resistance, and type 2 diabetes.
Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait.
TLDR
Using the NSY mouse, an inbred mouse model of type 2 diabetes, genetically dissected late-onset type 2abetes and demonstrated age-dependent changes in the genetic control of type 1 diabetes as well as polygenic inheritance.
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