T. Franklin

Publications84
h-index24
Citations2,408
Highly Influential Citations42
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The inhibition of nucleic acid synthesis by mycophenolic acid.
1. Mycophenolic acid, an antibiotic of some antiquity that more recently has been found to have marked activity against a range of tumours in mice and rats, strongly inhibits DNA synthesis in the L…
Biochemistry of Antimicrobial Action
TLDR
The development of antimicrobial agents, past, present and future and the problems of resistance to antimicrobial drugs.
Therapeutic approaches to organ fibrosis.
  • T. Franklin
  • Biology, Medicine
    The international journal of biochemistry & cell…
  • 1997
The Molecular Basis of Antibiotic Action
Mycophenolic Acid: an Anti-cancer Compound with Unusual Properties
TLDR
The aim was to detect substances having a more specific action than general lethality: substances which, for example, inhibit cell division or interfere with the mitotic mechanism.
Glucuronidation associated with intrinsic resistance to mycophenolic acid in human colorectal carcinoma cells.
TLDR
The rapid metabolism of mycophenolic acid by HT29 cells was associated with a markedly lower sensitivity to both the antiproliferative activity of the drug and to its ability to inhibit GTP synthesis, compared with cells lacking the capacity for significant glucuronidation.
Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones.
TLDR
The potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein.
Biochemistry and Molecular Biology of Antimicrobial Drug Action
The development of antimicrobial agents, past, present and future.- Vulnerable shields-the cell walls of bacteria and fungi.- Antimicrobial agents and cell membranes.- Inhibitors of nucleic acid…
Biochemistry of antimicrobial action. 3rd edition.
RESISTANCE OF ESCHERICHIA COLI TO TETRACYCLINES.
TLDR
Fractionation of cells cultured in medium containing [(14)C]chlortetracycline indicated that the largest proportion of radioactivity in sensitive cells was in the fraction consisting mainly of cell-wall material, while in the resistant cells there was no concentration ofRadioactivity.
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