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Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
TLDR
A simple and robust technique for the sequencing of proteins isolated by polyacrylamide gel electro-phoresis, using nano-electrospray3,4 tandem mass spectrometry5,6 and multiple-sequence stretches of up to 16 amino acids are obtained. Expand
The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
TLDR
It is reported that 2-methoxyoestradiol, an endogenous oestrogen metabolite of previously unknown function, is a potent inhibitor of endothelial cell proliferation and migration as well as angiogenesis in vitro. Expand
Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet.
TLDR
The urinary excretion of lignans was low but that of the isoflavonoids was very high and correlated with soybean-product intake, suggesting that the low mortality in breast and prostate cancer of Japanese women and men may be due to the high intake of soybean products. Expand
Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG).
TLDR
It is concluded that dietary macro- and micronutrients seem to play an important role in estrogen metabolism, and fiber intake and urinary excretion of lignans and phytoestrogens, and the concentration of plasma SHBG in women. Expand
Genistein, a dietary-derived inhibitor of in vitro angiogenesis.
TLDR
Genistein may represent a member of a new class of dietary-derived anti-angiogenic compounds that contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumors, by inhibiting neovascularization. Expand
Isotope dilution gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples.
TLDR
The simultaneous determination of the biologically most interesting phytoestrogens and lignans in foods has not been carried out previously and the method will be useful for screening of important foods in populations with different risk of cancer and coronary heart disease, and for metabolic studies. Expand
Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages.
TLDR
It is concluded that luteolin inhibits protein tyrosine phosphorylation, nuclear factor-kappaB-mediated gene expression and proinflammatory cytokine production in murine macrophages. Expand
Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry.
TLDR
It is concluded that a highly specific method for the assay of 3 lignans and 4 is oflavonoids in plasma has been developed and will be useful in future studies of lignan and isoflavonoid metabolism. Expand
Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis.
TLDR
Genistein may contribute to the preventive effect of plant-based diet on chronic diseases, including solid tumors, by inhibiting neovascularization and tumor cell proliferation and may have important applications in the treatment of solid tumors and angiogenic diseases. Expand
Luteolin Inhibits Vascular Endothelial Growth Factor-Induced Angiogenesis; Inhibition of Endothelial Cell Survival and Proliferation by Targeting Phosphatidylinositol 3′-Kinase Activity
TLDR
The flavonoid luteolin inhibited tumor growth and angiogenesis in a murine xenograft model and abolished VEGF-induced activation of Akt, a downstream target of PI3K conveying both survival and mitotic downstream signals. Expand
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