• Publications
  • Influence
The Evolutionary Genetics of Canalization
  • T. Flatt
  • Biology, Medicine
  • The Quarterly Review of Biology
  • 1 September 2005
Evolutionary genetics has recently made enormous progress in understanding how genetic variation maps into phenotypic variation. However, why some traits are phenotypically invariant despite apparentExpand
  • 348
  • 27
  • PDF
Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
Understanding how traits are integrated at the organismal level remains a fundamental problem at the interface of developmental and evolutionary biology. Hormones, regulatory signaling molecules thatExpand
  • 376
  • 22
  • PDF
Drosophila germ-line modulation of insulin signaling and lifespan
Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF)Expand
  • 259
  • 16
  • PDF
Size and shape: the developmental regulation of static allometry in insects
Among all organisms, the size of each body part or organ scales with overall body size, a phenomenon called allometry. The study of shape and form has attracted enormous interest from biologists, butExpand
  • 289
  • 16
  • PDF
Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America
Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an ancestrally tropical insect that hasExpand
  • 213
  • 16
  • PDF
Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles
The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here,Expand
  • 183
  • 14
  • PDF
Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
SUMMARY Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals forExpand
  • 170
  • 12
  • PDF
Survival costs of reproduction in Drosophila
  • T. Flatt
  • Biology, Medicine
  • Experimental Gerontology
  • 1 May 2011
Reproduction shortens lifespan in practically all organisms examined so far, but the underlying mechanisms remain largely unknown to date. Here I review what evolutionary and molecular biologistsExpand
  • 206
  • 10
  • PDF
Reproduction, fat metabolism, and life span: what is the connection?
Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies inExpand
  • 186
  • 9
  • PDF
VARIATION IN THERMAL PERFORMANCE AND REACTION NORMS AMONG POPULATIONS OF DROSOPHILA MELANOGASTER
The major goal of evolutionary thermal biology is to understand how variation in temperature shapes phenotypic evolution. Comparing thermal reaction norms among populations from different thermalExpand
  • 62
  • 8
  • PDF