• Publications
  • Influence
The Evolutionary Genetics of Canalization
  • T. Flatt
  • Biology, Medicine
  • The Quarterly Review of Biology
  • 1 September 2005
Evolutionary genetics has recently made enormous progress in understanding how genetic variation maps into phenotypic variation. However, why some traits are phenotypically invariant despite apparentExpand
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Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
Understanding how traits are integrated at the organismal level remains a fundamental problem at the interface of developmental and evolutionary biology. Hormones, regulatory signaling molecules thatExpand
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Drosophila germ-line modulation of insulin signaling and lifespan
Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF)Expand
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Size and shape: the developmental regulation of static allometry in insects
Among all organisms, the size of each body part or organ scales with overall body size, a phenomenon called allometry. The study of shape and form has attracted enormous interest from biologists, butExpand
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Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America
Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an ancestrally tropical insect that hasExpand
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Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles
The genomic basis of adaptation to novel environments is a fundamental problem in evolutionary biology that has gained additional importance in the light of the recent global change discussion. Here,Expand
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Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
SUMMARY Juvenile hormone (JH) and 20-hydroxy-ecdysone (20E) are highly versatile hormones, coordinating development, growth, reproduction and aging in insects. Pulses of 20E provide key signals forExpand
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Survival costs of reproduction in Drosophila
  • T. Flatt
  • Biology, Medicine
  • Experimental Gerontology
  • 1 May 2011
Reproduction shortens lifespan in practically all organisms examined so far, but the underlying mechanisms remain largely unknown to date. Here I review what evolutionary and molecular biologistsExpand
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Reproduction, fat metabolism, and life span: what is the connection?
Reduced reproduction is associated with increased fat storage and prolonged life span in multiple organisms, but the underlying regulatory mechanisms remain poorly understood. Recent studies inExpand
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The major goal of evolutionary thermal biology is to understand how variation in temperature shapes phenotypic evolution. Comparing thermal reaction norms among populations from different thermalExpand
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