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rpoS Mutations and Loss of General Stress Resistance in Escherichia coli Populations as a Consequence of Conflict between Competing Stress Responses
ABSTRACT The general stress resistance of Escherichia coli is controlled by the RpoS sigma factor (φS), but mutations in rpoS are surprisingly common in natural and laboratory populations. Evidence
A Regulatory Trade-Off as a Source of Strain Variation in the Species Escherichia coli
TLDR
It is demonstrated that variation in genome usage underpins intraspecific variability in transcription patterns, resistance to external stresses, and the choice of beneficial mutations under nutrient limitation and the evolutionary principle driving strain variation is proposed to be a conceptually novel trade-off that is named SPANC (for "self-preservation and nutritional competence").
Maintaining a healthy SPANC balance through regulatory and mutational adaptation
  • T. Ferenci
  • Biology, Medicine
    Molecular microbiology
  • 1 July 2005
TLDR
A holistic approach to bacterial adaptation, involving a gamut of regulation and mutation, is likely to be the norm in broadening the capabilities of a species, and a generalized hypothesis to explain bacterial adaptation is offered.
Hungry bacteria--definition and properties of a nutritional state.
  • T. Ferenci
  • Biology, Medicine
    Environmental microbiology
  • 1 October 2001
TLDR
Approaches to defining the hunger response in both molecular and growth kinetic terms are discussed, and gene expression changes unique to hunger conditions are described, using Escherichia coli as the primary example.
Regulation by nutrient limitation.
  • T. Ferenci
  • Biology, Medicine
    Current opinion in microbiology
  • 1 April 1999
TLDR
In Escherichia coli, recent results indicate that outermembrane permeability (porin and glycoporin regulation) as well as transport involving the phosphotransferase system and ABC-type high affinity transporters change under glucose limitation.
Adaptation to life at micromolar nutrient levels: the regulation of Escherichia coli glucose transport by endoinduction and cAMP.
  • T. Ferenci
  • Biology, Medicine
    FEMS microbiology reviews
  • 1 July 1996
TLDR
A novel mechanism of controlling bacterial transport affinity under sugar limitation is described, resulting in Escherichia coli orchestrating outer membrane changes as well as the induction of a periplasmic binding protein-dependent (ABC-type) transport system.
Effect of Slow Growth on Metabolism of Escherichia coli, as Revealed by Global Metabolite Pool (“Metabolome”) Analysis
TLDR
The results indicate that total metabolite pool ("metabolome") analysis offers a means of revealing novel aspects of cellular metabolism and global regulation.
The generation of multiple co-existing mal-regulatory mutations through polygenic evolution in glucose-limited populations of Escherichia coli.
TLDR
The multiplicity of alleles found within malT within a population derived from a single clone suggest that the periodic selection events observed previously in such populations are not a major factor in reducing genetic diversity.
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