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Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling.
TLDR
It is confirmed that MPS responses to AAs are transient, even with oral protein bolus, and changes in MPS only reflect elevated mTORC1 signaling during the upswing in M PS. Expand
Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells
TLDR
It is concluded that leucine is unique amongst the amino acids in its capacity to stimulate both mTOR and 4EBP1 phosphorylation and to enhance p70S6K1 signalling. Expand
Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism
TLDR
It is reported here that HMB stimulates muscle protein synthesis to a similar extent to leucine, and HMB was also found to decrease muscle protein breakdown. Expand
Effects of hypoxia on muscle protein synthesis and anabolic signaling at rest and in response to acute resistance exercise.
TLDR
It is concluded that normobaric hypoxia does not reduce MPS over 3.5 h at rest but blunts the increased MPS response to acute RE to a degree dependent on extant SpO(2). Expand
A single protein meal increases recovery of muscle function following an acute eccentric exercise bout.
TLDR
Ingestion of a single post-exercise protein mixture increases the rate of force and power restoration at 48 h, suggesting potential for protein as an ergogenic aid during the DOMS period. Expand
Calpains Mediate Integrin Attachment Complex Maintenance of Adult Muscle in Caenorhabditis elegans
TLDR
In vivo evidence is provided that a calpain-based molecular repair mechanism exists for dealing with attachment complex disruption in adult muscle and that calpains are required for proper assembly and maintenance of integrin attachment complexes. Expand
"Nutraceuticals" in relation to human skeletal muscle and exercise.
TLDR
Existing evidence surrounding the efficacy of a nonexhaustive list of macronutrient, micronutrients, and "nutraceutical" compounds alone and in combination with exercise in relation to skeletal muscle mass, metabolism (protein and fuel), and exercise performance is detailed. Expand
Network analysis of human muscle adaptation to aging and contraction
TLDR
A network-driven pipeline was employed to identify putative molecular drivers of muscle aging and contraction mode responses and identified two contraction ‘responsive’ modules that correlated with the magnitude of post-exercise muscle strength decline. Expand
Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans
TLDR
In worms grown from the L1 larval stage to adulthood under microgravity, both gene and protein expression levels for muscular thick filaments, cytoskeletal elements and mitochondrial metabolic enzymes decreased relative to parallel cultures on the 1-G centrifuge. Expand
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