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A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects?
The data suggest that the combined heterozygosity for the two MTHFR common mutations accounts for a proportion of folate-related NTDs, which is not explained by homozygosity by the 677(C-->T) mutation, and can be an additional genetic risk factor for N TDs.
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent…
- W. Nelen, H. Blom, C. M. Thomas, E. Steegers, G. Boers, T. Eskes
- MedicineThe Journal of nutrition
- 1 August 1998
To determine the effects of daily supplementation of 0.5 mg folic acid on homocysteine and folate concentrations, we investigated 49 women with a history of unexplained recurrent miscarriages. A…
Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial.
Increasing the consumption of vegetables and citrus fruit, both good sources of folate, will improve folate status and decrease tHcy concentrations, which may contribute to the prevention of cardiovascular disease and NTD in the general population.
Hyperhomocysteinemia and recurrent early pregnancy loss: a meta-analysis.
Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial.
- I. Brouwer, M. van Dusseldorp, R. Steegers-Theunissen
- MedicineThe American journal of clinical nutrition
Doses of folic acid as low as 250 microgram/d, on average, in addition to usual dietary intakes of folate significantly decreased plasma total homocysteine concentrations in healthy, young women.
Maternal hyperhomocysteinemia: a risk factor for neural-tube defects?
Neural-tube defects and derangement of homocysteine metabolism.
Is the common 677C-->T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis.
- N. V. D. van der Put, T. Eskes, H. Blom
- Biology, MedicineQJM : monthly journal of the Association of…
- 1 February 1997
A meta-analysis confirms that the 677C-->T mutation is a genetic risk factor for NTD.