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Similarities and differences among 105 members of the Int family of site-specific recombinases.
Alignments of 105 site-specific recombinases belonging to the Int family of proteins identified extended areas of similarity and three types of structural differences. In addition to the previouslyExpand
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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
DNA polymerases change their specificity for nucleotide substrates with each catalytic cycle, while achieving error frequencies in the range of 10 −5to 10−6. Here we present a 2.2 Å crystal structureExpand
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Crystal Structure of T7 Gene 4 Ring Helicase Indicates a Mechanism for Sequential Hydrolysis of Nucleotides
We have determined the crystal structure of an active, hexameric fragment of the gene 4 helicase from bacteriophage T7. The structure reveals how subunit contacts stabilize the hexamer. DeviationExpand
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Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer.
A large group of transcription factors regulating cell growth and differentiation share a dimeric alpha-helical DNA-binding domain termed the basic region helix-loop-helix (bHLH). bHLH proteinsExpand
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Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.
Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75, which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant cellularExpand
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Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
DNA interstrand crosslinks (ICLs) can be induced by multiple crosslinking agents and are a severe form of DNA damage that prevents strand separation during DNA replication and transcription. FailureExpand
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Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA
The Escherichia coli Rob protein is a transcription factor belonging to the AraC/XylS protein family that regulates genes involved in resistance to antibiotics, organic solvents and heavy metals. TheExpand
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Eukaryotic DNA ligases: structural and functional insights.
DNA ligases are required for DNA replication, repair, and recombination. In eukaryotes, there are three families of ATP-dependent DNA ligases. Members of the DNA ligase I and IV families are found inExpand
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DNA bending and a flip‐out mechanism for base excision by the helix–hairpin–helix DNA glycosylase, Escherichia coli AlkA
The Escherichia coli AlkA protein is a base excision repair glycosylase that removes a variety of alkylated bases from DNA. The 2.5 Å crystal structure of AlkA complexed to DNA shows a largeExpand
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A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.
DNA sliding clamps encircle DNA and provide binding sites for many DNA-processing enzymes. However, it is largely unknown how sliding clamps like proliferating cell nuclear antigen (PCNA) coordinateExpand
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