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Prevalence of Depression During Pregnancy: Systematic Review
TLDR
Rates of depression, especially during the second and third trimesters of pregnancy, are substantial, and clinical and economic studies to estimate maternal and fetal consequences are needed.
Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007–2017
TLDR
CVD is a major cause of mortality among people with T2DM, accounting for approximately half of all deaths over the study period, and overall CVD affects approximately 32.2% of all persons with T 2DM.
Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis.
TLDR
A meta-analysis of randomized, double-blind, placebo-controlled, parallel-group trials of currently marketed ChEIs, used in therapeutic doses for at least 12 weeks, results in a modest but significant therapeutic effect and modestly but significantly higher rates of adverse events and discontinuation of treatment.
The safety of anti-tumour necrosis factor treatments in rheumatoid arthritis: meta and exposure-adjusted pooled analyses of serious adverse events.
TLDR
Meta-analytic and exposure-adjusted pooled analyses on over 8800 RA subjects in RCT treated over an average of 0.8 years did not identify an increased risk of serious adverse events with recommended doses, and meta-regression identified that the risk ofserious infection with anti-TNF therapy decreases with increasing trial duration.
Methods for Quantification of Exposure to Cigarette Smoking and Environmental Tobacco Smoke: Focus on Developmental Toxicology
TLDR
The sensitivity, specificity, and clinical utilization of different methods used to estimate exposure to cigarette smoking and environmental tobacco smoke are defined.
Drug utilization 90% – a simple method for assessing the quality of drug prescribing
TLDR
The idea that the number of drugs accounting for 90% of drug use – drug utilization 90% (DU90%) – may serve as an indicator of the quality of drug prescribing in routine health care is tested.
Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses.
TLDR
In the first year of treatment for CHB, tenofovir and entecavir are the most potent oral antiviral agents for HBeAg-positive patients; ten ofovir is most effective for H beAg-negative patients.
Sensitivity of Patient Outcomes to Pharmacist Interventions. Part I: Systematic Review and Meta-Analysis in Diabetes Management
TLDR
A1C is sensitive to pharmacists' interventions and several potentially sensitive outcomes were identified, but too few studies were available for quantitative summaries.
Pregnancy outcome following maternal organic solvent exposure: a meta-analysis of epidemiologic studies.
TLDR
Maternal occupational exposure to organic solvents is associated with a tendency toward an increased risk for spontaneous abortion and additional studies may affect the trend.
Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies.
TLDR
Although prednisone does not represent a major teratogenic risk in humans at therapeutic doses, it does increase by an order of 3.4-fold the risk of oral cleft, which is consistent with the existing animal studies.
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