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eIF4A Inhibition Allows Translational Regulation of mRNAs Encoding Proteins Involved in Alzheimer's Disease
- A. Bottley, Nicola M. Phillips, T. E. Webb, A. Willis, K. Spriggs
- Biology, Medicine
- PloS one
- 28 September 2010
Alzheimer's disease (AD) is the main cause of dementia in our increasingly aging population. The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing… Expand
Effects of 5-azacytidine on polyribosomes and on the control of tyrosine transaminase activity in rat liver.
Abstract 1. 1. The effects of the nucleoside analog 5-azacytidine on general protein biosynthesis in rat liver, and on the induction and inactivation of hepatic tyrosine transaminase and tryptophan… Expand
Uridine kinase activities and pyrimidine nucleoside phosphorylation in fluoropyrimidine-sensitive and -resistant cell lines of the Novikoff hepatoma.
Uridine kinase, the rate-limiting enzyme in the activation (phosphorylation) of uridine and the corresponding chemotherapeutic analogues, is present as two isoenzymes localized exclusively in the… Expand
Ribosome formation in rat liver: evidence for post-transcriptional control.
Abstract An investigation of the amount of label incorporated from [6- 14 C]orotic acid into the nuclear and cytoplasmic ribosomal RNA of non-proliferating rat liver, during a 1-h treatment with… Expand
Characterization of a messenger RNA transport protein.
A cytoplasmic protein which facilitates the energy-dependent transport of mRNA from isolated nuclei to a specified medium has been further characterized, since it could have relevance to the… Expand
Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis.
Serum beta-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL/6 less than BALB/c, DBA/2, ICR less than… Expand
Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits.
- C. Dwivedi, W. J. Heck, A. Downie, S. Larroya, T. E. Webb
- Chemistry, Medicine
- Biochemical medicine and metabolic biology
- 1 April 1990
Glucarate is normally present in tissues and body fluids and is in equilibrium with D-glucaro-1,4-lactone, a natural inhibitor of beta-glucuronidase activity. Dietary calcium glucarate, a… Expand
Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug
- Lindsay E. Evans, Aishwarya Krishna, +7 authors A. M. Edwards
- Chemistry, Medicine
- Journal of medicinal chemistry
- 22 April 2019
Expression of β-lactamase is the single most prevalent determinant of antibiotic resistance, rendering bacteria resistant to β-lactam antibiotics. In this article, we describe the development of an… Expand
Regulated transport of messenger ribonucleic acid from isolated liver nuclei by nucleic acid binding proteins.
Rat liver nucleocytosolic messenger ribonucleic acid (mRNA) transport is shown to be regulated by proteins with a high affinity for nucleic acids. In the cell-free system described, the… Expand
Transport of informosomes from isolated nuclei of regenerating rat liver.
Abstract Nuclei, isolated from regenerating rat liver following a 30-minute prelabelling in vivo with orotic acid-6- 14 C, are shown to release rapidly labelled RNA in informosome-like particles in… Expand