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Relative changes of cerebral arterial and venous blood volumes during increased cerebral blood flow: Implications for BOLD fMRI
Measurement of cerebral arterial and venous blood volumes during increased cerebral blood flow can provide important information regarding hemodynamic regulation under normal, pathological, andExpand
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Localized cerebral blood flow response at submillimeter columnar resolution
Functional magnetic resonance imaging (fMRI) has been widely used for imaging brain functions. However, the extent of the fMRI hemodynamic response around the active sites, at submillimeterExpand
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Microvascular BOLD contribution at 4 and 7 T in the human brain: Gradient‐echo and spin‐echo fMRI with suppression of blood effects
The BOLD signal consists of an intravascular (IV) and an extravascular (EV) component from both small and large vessels. Their relative contributions are dependent on field strength, imagingExpand
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Spin‐echo fMRI in humans using high spatial resolutions and high magnetic fields
The Hahn spin‐echo (HSE)‐based BOLD effect at high magnetic fields is expected to provide functional images that originate exclusively from the microvasculature. The blood contribution that dominatesExpand
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High-resolution mapping of iso-orientation columns by fMRI
Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is an important tool for localizing brain functions in vivo. However, the ability of BOLD fMRI to map corticalExpand
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Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals
Functional magnetic resonance imaging (fMRI) was used to investigate the effects of inspired hypoxic, hyperoxic, and hypercapnic gases on baseline and stimulus-evoked changes in blood oxygenationExpand
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Functional MRI of calcium‐dependent synaptic activity: Cross correlation with CBF and BOLD measurements
Spatial specificities of the calcium‐dependent synaptic activity, hemodynamic‐based blood oxygenation level‐dependent (BOLD) and cerebral blood flow (CBF) fMRI were quantitatively compared in theExpand
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Spatiotemporal dynamics of the BOLD fMRI signals: Toward mapping submillimeter cortical columns using the early negative response
The existence of the early‐negative blood‐oxygenation‐level‐dependent (BOLD) response is controversial and its practical utility for mapping brain functions with columnar spatial specificity remainsExpand
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High‐resolution, spin‐echo BOLD, and CBF fMRI at 4 and 7 T
With growing interest in noninvasive mapping of columnar organization and other small functional structures in the brain, achieving high spatial resolution and specificity in fMRI is of criticalExpand
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Evaluation of extra‐ and intracellular apparent diffusion in normal and globally ischemic rat brain via 19F NMR
The biophysical mechanism(s) underlying diffusion‐weighted MRI contrast following brain injury remains to be elucidated. Although it is generally accepted that water apparent diffusion coefficientExpand
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