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Mitochondrial DNA analysis in Tibet: implications for the origin of the Tibetan population and its adaptation to high altitude.
It is suggested that mtDNA mutations are unlikely to play a major role in the adaptation of Tibetans to high altitudes and is supportive of previous genetic evidence that Tibetans, although located in southern Asia, share common ancestral origins with northern Mongoloid populations.
Minimal hypoxic pulmonary hypertension in normal Tibetans at 3,658 m.
This small sample of healthy Tibetans with lifelong residence had resting pulmonary arterial pressures that were normal by sea-level standards and exhibited minimal hypoxic pulmonary vasoconstriction, both at rest and during exercise, consistent with remarkable cardiac performance and high-altitude adaptation.
Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude
- L. Moore, D. Young, R. McCullough, T. Droma, S. Zamudio
- BiologyAmerican journal of human biology : the official…
- 1 September 2001
It is suggested that those living at high altitude the longest have the least altitude‐associated intrauterine growth restriction and have lower levels of prenatal and postnatal mortality than those living there for a shorter period of time.
Hypoxic ventilatory responsiveness in Tibetan compared with Han residents of 3,658 m.
It is concluded that lifelong Tibetan residents of high altitude neither hypoventilated nor exhibited blunted hypoxic ventilatory responses compared with acclimatized Han newcomers, suggesting that the effects of lifelong high-altitude residence on ventilation and ventilatories response to hypoxia differ in Tibetan compared with other high-ALTitude populations.
Greater maximal O2 uptakes and vital capacities in Tibetan than Han residents of Lhasa.
Smaller alveolar-arterial O2 gradients in Tibetan than Han residents of Lhasa (3658 m).
Effect of altitude on uterine artery blood flow during normal pregnancy.
- S. Zamudio, S. Palmer, T. Droma, E. Stamm, C. Coffin, L. Moore
- Medicine, BiologyJournal of applied physiology
- 1 July 1995
It is concluded that reduced uterine blood flow and altered pelvic blood flow distribution during pregnancy at high altitude likely contributed to the altitude-associated reduction in infant birth weight.
Increased vital and total lung capacities in Tibetan compared to Han residents of Lhasa (3,658 m).
Tibetans' vital capacity and total lung capacity in relation to body size were similar to values reported previously for lifelong residents of high altitude in South and North America, and Tibetans, like North and South American high-altitude residents, have larger lung volumes.
Protection from intrauterine growth retardation in Tibetans at high altitude.
Data support the hypothesis that Tibetans are protected from altitude-associated intrauterine growth retardation and suggest that selection for optimization of birth weight at high altitude has occurred in Tibetans.