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Unitary Assembly of Presynaptic Active Zones from Piccolo-Bassoon Transport Vesicles
Recent studies indicate that active zones (AZs)-sites of neurotransmitter release-may be assembled from preassembled AZ precursor vesicles inserted into the presynaptic plasma membrane. Here weExpand
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Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon
Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites ofExpand
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Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation
Cell adhesion molecules are key players in transsynaptic communication, precisely coordinating presynaptic differentiation with postsynaptic specialization. At glutamatergic synapses, theirExpand
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Neuroligins and neurexins: linking cell adhesion, synapse formation and cognitive function
Cell adhesion represents the most direct way of coordinating synaptic connectivity in the brain. Recent evidence highlights the importance of a trans-synaptic interaction between postsynapticExpand
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Structurally and functionally unique complexins at retinal ribbon synapses
Ribbon synapses in retinal sensory neurons maintain large pools of readily releasable synaptic vesicles. This allows them to release several hundreds of vesicles per second at every presynapticExpand
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Local Sharing as a Predominant Determinant of Synaptic Matrix Molecular Dynamics
Recent studies suggest that central nervous system synapses can persist for weeks, months, perhaps lifetimes, yet little is known as to how synapses maintain their structural and functionalExpand
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The presynaptic cytomatrix of brain synapses
Abstract. Synapses are principal sites for communication between neurons via chemical messengers called neurotransmitters. Neurotransmitters are released from presynaptic nerve terminals at theExpand
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Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion.
The membrane protein syntaxin participates in several protein-protein interactions that have been implicated in neurotransmitter release. To probe the physiological importance of these interactions,Expand
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Functional regions of the presynaptic cytomatrix protein bassoon: significance for synaptic targeting and cytomatrix anchoring
Exocytosis of neurotransmitter from synaptic vesicles is restricted to specialized sites of the presynaptic plasma membrane called active zones. A complex cytomatrix of proteins exclusively assembledExpand
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The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis.
BACKGROUND Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis. They regulate vesicle transport by bindingExpand
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