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Redox signaling triggers protection during the reperfusion rather than the ischemic phase of preconditioning
TLDR
Redox signaling occurs during the reperfusion phase of ischemic preconditioning (IPC), and the critical component in that reperfusions phase appears to be molecular oxygen.
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Redox signaling at reperfusion is required for protection from ischemic preconditioning but not from a direct PKC activator
TLDR
It is concluded that while redox signaling during the first few minutes of reperfusion is an essential component of preconditioning’s protective mechanism, this step occurs upstream of PKC activation.
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Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C.
TLDR
CPT targets PKG, which activates PKC through mitochondrial K(ATP) channel (mitoKATP)-dependent redox signaling, a sequence mimicking that already documented in preconditioning, and augments sensitivity of normally low-affinity cardiac adenosine A2b receptors so endogenous adenosines can protect by activating Akt and ERK.
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Involvement of NMDA receptors and nitric oxide in the thermoregulatory effect of morphine in mice
TLDR
The results further support the relationship between NO and NMDA receptors and suggest a possible role of NMDA-NO pathway in the thermoregulatory effect of morphine.
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Protective effects of silymarin against doxorubicin-induced toxicity.
TLDR
Results of the present study indicate that silymarin significantly protected doxorubicin-induced toxicities to the rat kidney, heart, and liver, thus suggesting its administration as a supportive care agent during anti-cancer treatment featuring doxorbicin.
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Antidepressant-like effects of the xanthine oxidase enzyme inhibitor allopurinol in rats. A comparison with fluoxetine
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The protective effect of nitroglycerin on gastrointestinal and renal side effects of lornoxicam in rats.
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Cardioprotective properties of the platelet P2Y12 receptor inhibitor prasugrel on cardiac ischemia/reperfusion injury.
  • T. Dost
  • Biology, Medicine
    Pharmacological reports : PR
  • 13 January 2020
TLDR
The selective P2Y12 inhibitor prasugrel provides effective protection against myocardial infarction and ischemia-induced ventricular arrhythmias in rats as in ischemic postconditioning.
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[The effects of combination of two lornoxicam doses and nitroglycerine on acute pain in rats].
TLDR
In conclusion, 1.3 mg/kg dose of lornoksicam with the use of nitrogliserine provided early and efficient analgesia, but the increasing doses did not maintain better analgesia.
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The Effect of Hypericum perforatum (St. John’s Wort) on Experimental Colitis in Rat
TLDR
HP has a protective effect on TNBS-induced inflammatory bowel disease (IBD), probably due to an anti-inflammatory and antioxidant mechanism.
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