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GeneCards Version 3: the human gene integrator
TLDR
A key focus is on gene-set analyses, which leverage GeneCards’ unique wealth of combinatorial annotations, which address a host of applications, including microarray data analysis, cross-database annotation mapping and gene-disorder associations for drug targeting.
Dual resistance of melon to Fusarium oxysporum races 0 and 2 and to Papaya ring-spot virus is controlled by a pair of head-to-head-oriented NB-LRR genes of unusual architecture.
TLDR
This study focused on the Fom-1 gene, which confers resistance to races 0 and 2 (Risser et al.,1976), and on the Prv gene; the two are tightly linked on melon linkage group iX.
A genome-wide analysis of C/D and H/ACA-like small nucleolar RNAs in Trypanosoma brucei reveals a trypanosome-specific pattern of rRNA modification.
TLDR
The large repertoire of modifications and guide RNAs in trypanosomes suggests that these modifications possibly play a central role in these parasites.
ElemeNT: a computational tool for detecting core promoter elements
TLDR
The Elements Navigation Tool (ElemeNT) is a user-friendly web-based, interactive tool for prediction and display of putative core promoter elements and their biologically-relevant combinations, and the CORE database summarizes ElemeNT-predicted core promoter Elements near CAGE and RNA-seq-defined Drosophila melanogaster transcription start sites (TSSs).
Elucidating the Role of C/D snoRNA in rRNA Processing and Modification in Trypanosoma brucei
TLDR
MRP RNA, which is involved in rRNA processing, was identified in this study in one of the snoRNA gene clusters, suggesting that trypanosomes utilize a combination of unique C/D sno RNAs and conserved snoRNAs for r RNA processing.
The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family
TLDR
This is the first report of a TER that binds the C/D snoRNA core proteins and associates with the methyltransferase‐associated protein (MTAP), whose homologue binds to mammalian TER.
Genome-wide analysis of small nucleolar RNAs of Leishmania major reveals a rich repertoire of RNAs involved in modification and processing of rRNA
TLDR
This study analyzed the complete repertoire of Leishmania major small nucleolar (snoRNA) RNAs by performing RNA-seq analysis on RNAs that were affinity-purified using the C/D snoRNA core protein, SNU13, and the H/ACA coreprotein, NHP2 to elucidate how snoRNAs evolved to generate molecules with analogous functions in both species.
RNA-seq analysis of small RNPs in Trypanosoma brucei reveals a rich repertoire of non-coding RNAs
TLDR
The power of deep sequencing of RNA (RNA-seq) was employed to examine the repertoire of ncRNAs present in small ribonucleoprotein particles (RNPs) of Trypanosoma brucei, an important protozoan parasite, and demonstrated that three highly abundant snoRNAs are involved in rRNA processing and highlight the unique trypanosome-specific repertoire of these RNAs.
Sustainability of coral reefs are affected by ecological light pollution in the Gulf of Aqaba/Eilat
TLDR
Genes involved in regulating the cell cycle and cell growth are differentially expressed when corals are exposed to ecological light pollution, confirming that ELP acts as a chronic disturbance that may impact the future of coral reefs.
Diversification of stem cell molecular repertoire by alternative splicing.
TLDR
Computational and experimental methods are combined to identify splice variants in embryonic and hematopoietic stem cells on a genome-wide scale and reveal extensive modification of the stem cell molecular repertoire by alternative splicing and provide insights into its overall role as a mechanism of generating genomic diversity.
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