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Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey.
Azathioprine (AZA) is cleaved in vivo by glutathione to 6-mercpatopurine (6-MP). 6-MP plasma levels were measured by HPLC in four male rhesus monkeys following oral and iv doses of the two drugs.… Expand
Determination of 6-mercaptopurine and azathioprine in plasma by high-performance liquid chromatography.
Using 1-ml plasma samples, levels of 6-mercaptopurine (6MP) as low as 5 ng/ml and azathioprine (AZA) as low as 40 ng/ml can be detected using a high-performance liquid chromatography reversed-phase… Expand
Effect of Mylanta on Naproxen Bioavailability
- S. S. Weber, A. Bankhurst, E. Mroszczak, T. Ding
- Chemistry, Medicine
- Therapeutic drug monitoring
- 1 September 1981
Summary The effect of Mylanta on naproxen bioavailability was studied in 11 healthy volunteers. In separate experiments, single oral doses of naproxen (250 mg) and multiple oral doses (250 mg twice… Expand
The reversible biotransformation of N-acetylprocainamide in the rhesus monkey.
The specific activity of 14C-N-acetylprocainamide (14C-NAPA) was measured in the 24-h urine of two rhesus monkeys given the labelled drug i.v. Specific activity was found to decrease by 15.8% from… Expand
Selective α1B- and α1D-adrenoceptor antagonists suppress noradrenaline-induced activation, proliferation and ECM secretion of rat hepatic stellate cells in vitro
Aim:To explore the effects of noradrenaline (NA) on hepatic stellate cells (HSCs) in vitro and to determine the adrenoceptor (AR) subtypes and underlying mechanisms.Methods:The distribution and… Expand
[Clinical significance of inflammatory reaction in patients with coronary heart disease].
- Y. Wang, T. Ding, Ling-ling Zhang, Jia-chun Yan, X. Yu, J. Shi
- Xi bao yu fen zi mian yi xue za zhi = Chinese…
- 1 September 2003
AIM To explore the relationship between inflammatory reaction and coronary heart disease (CHD). METHODS 101 CHD patients were divided into 3 groups, namely 19 ca-ses of stable angina pectoris (… Expand
Mining Drugs and Indications for Suicide-Related Adverse Events
A pharmacovigilance analysis was conducted to better understand drugs and indications as risk factors for suicide using data from the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). Expand
The effect of the novel small molecule drug 54118 on the C-X-C chemokine receptor type 4 in the context of cancer cell metastasis
Analysis of the relationship between plasma D-dimer and hepatic functional reserve status in patients with hepatitis B
Objective To investigate the relationship between the level of plasma D-dimer(D-D) and hepatic functional reserve status in patients with hepatitis B (HB).Methods 77 cases with HB were divided into… Expand
The relationship between inflammation of blood vessels and microcirculation disturbance in liver of patients with chronic hepatitis B
- T. Ding
- 1 December 2010
Objective To study the effects of inflammation of blood vessels to microcirculation disturbance in liver of patients with chronic hepatitis B(CHB). Methods 188 cases of hepatic tissue with CHB were… Expand