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The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks.
The neuronal response patterns that are required for an adequate behavioural reaction to subjectively relevant changes in the environment are commonly studied by means of oddball paradigms, in whichExpand
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Application and comparison of classification algorithms for recognition of Alzheimer's disease in electrical brain activity (EEG)
The early detection of subjects with probable Alzheimer's disease (AD) is crucial for effective appliance of treatment strategies. Expand
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Molecular Basis for Multiple Sulfatase Deficiency and Mechanism for Formylglycine Generation of the Human Formylglycine-Generating Enzyme
Sulfatases are enzymes essential for degradation and remodeling of sulfate esters. Formylglycine (FGly), the key catalytic residue in the active site, is unique to sulfatases. In higher eukaryotes,Expand
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Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity.
HS (heparan sulfate) is essential for normal embryonic development. This requirement is due to the obligatory role for HS in the signalling pathways of many growth factors and morphogens that bind toExpand
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Multiple Sulfatase Deficiency Is Caused by Mutations in the Gene Encoding the Human Cα-Formylglycine Generating Enzyme
C(alpha)-formylglycine (FGly) is the catalytic residue in the active site of eukaryotic sulfatases. It is posttranslationally generated from a cysteine in the endoplasmic reticulum. The geneticExpand
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Functional Imaging of Visuospatial Processing in Alzheimer's Disease
Alzheimer's disease (AD) is known to cause a variety of disturbances of higher visual functions that are closely related to the neuropathological changes. Expand
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Sulf Loss Influences N-, 2-O-, and 6-O-Sulfation of Multiple Heparan Sulfate Proteoglycans and Modulates Fibroblast Growth Factor Signaling*
Sulf1 and Sulf2 are two heparan sulfate 6-O-endosulfatases that regulate the activity of multiple growth factors, such as fibroblast growth factor and Wnt, and are essential for mammalian developmentExpand
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Sequence determinants directing conversion of cysteine to formylglycine in eukaryotic sulfatases
Sulfatases carry at their catalytic site a unique post‐translational modification, an α‐formylglycine residue that is essential for enzyme activity. Formylglycine is generated by oxidation of aExpand
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The Iron Sulfur Protein AtsB Is Required for Posttranslational Formation of Formylglycine in the Klebsiella Sulfatase*
The catalytic residue of eukaryotic and prokaryotic sulfatases is a α-formylglycine. In the sulfatase ofKlebsiella pneumoniae the formylglycine is generated by posttranslational oxidation of serineExpand
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Semantic memory involvement in the default mode network: A functional neuroimaging study using independent component analysis
The Default Mode Network (DMN) is a higher order functional network that displays activation during passive rest and deactivation during many types of cognitive tasks. Expand
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