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Aspirin and clopidogrel drug response in patients undergoing percutaneous coronary intervention: the role of dual drug resistance.
UNLABELLED We evaluated the response to clopidogrel among aspirin-resistant versus aspirin-sensitive patients undergoing elective coronary stenting. Patients (n = 150) treated with aspirin but notExpand
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Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery disease.
OBJECTIVES The aim of this study was to evaluate the relationship between reticulated platelets (RPs), platelet size, and platelet function in patients with stable coronary artery disease (CAD)Expand
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Reticulated platelets and uninhibited COX‐1 and COX‐2 decrease the antiplatelet effects of aspirin
Background: The mechanisms for the variability in antiplatelet effects of aspirin are unclear. Immature (reticulated) platelets may modulate the antiplatelet effects of aspirin through uninhibitedExpand
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Association of immature platelets with adverse cardiovascular outcomes.
BACKGROUND Immature platelets are less responsive to the effects of antiplatelet drugs and contain messenger ribonucleic acid that is translationally active. They can be measured easily using anExpand
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Immature platelet fraction (IPF) determined with an automated method predicts clopidogrel hyporesponsiveness
The mechanisms for the variability in antiplatelet effects of clopidogrel are not elucidated entirely. Immature (reticulated) platelets may modulate the antiplatelet effects of clopidogrel but mustExpand
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Platelet reactivity and response to aspirin in subjects with the metabolic syndrome.
BACKGROUND Metabolic syndrome (MS) is associated with a prothrombotic state and predicts the subsequent development of type 2 diabetes mellitus. We hypothesized that similar to diabetes, subjectsExpand
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Platelet reactivity in patients with subacute stent thrombosis compared with non-stent-related acute myocardial infarction.
BACKGROUND Recent case control studies suggest that patients with subacute stent thrombosis (SAT) have increased platelet reactivity. However, SAT often presents as acute myocardial infarction (AMI),Expand
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Increased platelet sensitivity among individuals with aspirin resistance - platelet aggregation to submaximal concentration of arachidonic acid predicts response to antiplatelet therapy.
Aspirin 'resistance' (AR) is a phenomenon of uncertain etiology describing decreased platelet inhibition by aspirin. We studied whether (i) platelets in AR demonstrate increased basal sensitivity toExpand
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Detection and quantification of circulating immature platelets: agreement between flow cytometric and automated detection
Abstract Immature platelets—also termed reticulated platelets (RP)—are platelets newly released into the circulation, and have been associated with a variety of pathological thrombotic events. TheyExpand
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Effect of ranitidine on the antiplatelet effects of aspirin in healthy human subjects.
Aspirin is often taken with H2-receptor antagonists. In vitro data suggest that certain antagonists, such as ranitidine, have inhibitory effects on platelet function. There are no reports on theExpand
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