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Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of muscle atrophy, we performed transcript profiling. Although many genesExpand
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Parental imprinting of the mouse insulin-like growth factor II gene
We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygousExpand
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The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo
Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highlyExpand
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Agrin Acts via a MuSK Receptor Complex
Formation of th neuromuscular junction depends upon reciprocal inductive interactions between the developing nerve and muscle, resulting in the precise juxtaposition of a differentiated nerveExpand
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Requirement of FGF-4 for postimplantation mouse development
Fibroblast growth factors (FGFs) are thought to influence many processes in vertebrate development because of their diverse sites of expression and wide range of biological activities in in vitroExpand
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Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina.
Lineage analyses of vertebrate retinae have led to the suggestions that cell fate decisions are made during or after the terminal cell division and that extrinsic factors can influence fate choices.Expand
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Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
Ciliary neurotrophic factor (CNTF) supports motor neuron survival in vitro and in mouse models of motor neuron degeneration and was considered a candidate for the muscle-derived neurotrophic activityExpand
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High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
One of the most effective approaches for determining gene function involves engineering mice with mutations or deletions in endogenous genes of interest. Historically, this approach has been limitedExpand
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Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B
Inherited limb malformations provide a valuable resource for the identification of genes involved in limb development. Brachydactyly type B (BDB), an autosomal dominant disorder, is the most severeExpand
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Loss-of-Function Analysis of EphA Receptors in Retinotectal Mapping
EphA tyrosine kinases are thought to act as topographically specific receptors in the well-characterized projection map from the retina to the tectum. Here, we describe a loss-of-function analysis ofExpand
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