• Publications
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Voltage-gated proton channels and other proton transfer pathways.
  • T. DeCoursey
  • Medicine, Chemistry
  • Physiological reviews
  • 1 April 2003
Proton channels exist in a wide variety of membrane proteins where they transport protons rapidly and efficiently. Usually the proton pathway is formed mainly by water molecules present in theExpand
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The voltage dependence of NADPH oxidase reveals why phagocytes need proton channels
The enzyme NADPH oxidase in phagocytes is important in the body's defence against microbes: it produces superoxide anions (O2-, precursors to bactericidal reactive oxygen species). Electrons moveExpand
  • 267
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Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?
Membrane receptors and ion transport mechanisms probably have an important role in lymphocyte activation leading to T-lymphocyte proliferation in the immune response. Here we have applied aExpand
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A voltage-gated potassium channel in human T lymphocytes.
Human peripheral T lymphocytes were studied at 20-24 degrees C using the gigaohm seal recording technique in whole-cell or outside-out patch conformations. The predominant ion channel present underExpand
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Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.
  • T. DeCoursey
  • Medicine, Physics
  • Physiological reviews
  • 1 April 2013
Voltage-gated proton channels (H(V)) are unique, in part because the ion they conduct is unique. H(V) channels are perfectly selective for protons and have a very small unitary conductance, bothExpand
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Regulation and termination of NADPH oxidase activity
Abstract.NADPH oxidase of phagocytes plays a crucial role in host defense by producing reactive oxygen species (ROS) that are intended to kill invading microbes. Many other cells produce ROS forExpand
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HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species
Voltage-gated proton currents regulate generation of reactive oxygen species (ROS) in phagocytic cells. In B cells, stimulation of the B cell antigen receptor (BCR) results in the production of ROSExpand
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Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils.
Generation of reactive oxygen species by the NADPH oxidase complex is an important bactericidal weapon of phagocytes. Phorbol myristate acetate (PMA) is a potent agonist for this "respiratory burst"Expand
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Voltage-gated potassium channels are required for human T lymphocyte activation
The calcium channel blockers, verapamil and diltiazem, inhibit phytohemagglutinin (PHA)-induced mitogenesis at concentrations that block the T lymphocyte K channel currents. K channel blockers alsoExpand
  • 182
  • 8
Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis
Phagocytosis of microbial invaders represents a fundamental defense mechanism of the innate immune system. The subsequent killing of microbes is initiated by the respiratory burst, in whichExpand
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