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Associations between genetic polymorphisms and bipolar disorder Associação entre polimorfismos genéticos e transtorno bipolar
- V. Alves, Aline Cristine Pereira e Silva, Valfrido Leão de Melo Neto, T. De, Andrade, Antonio Egidio Nardi
- Psychology, Biology
It was showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.
Genetic association of primary nonresponse to anti-TNFα therapy in patients with inflammatory bowel disease
A variant rs34767465 associated with PNR to anti-TNFα biologics is identified, which increases TNFα secretion through mechanism related to autophagy, which may also explain the comorbidities associated with IBD.
Patterns of presentations of children to emergency departments across Europe and the impact of the COVID-19 pandemic: retrospective observational multinational study.
Reductions in ED attendances were seen across Europe during the first COVID-19 lockdown period, and were highest and sustained throughout the study period for children with communicable infectious diseases.