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New cell lines from mouse epiblast share defining features with human embryonic stem cells
The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and theExpand
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Constitutive expression of the machinery for programmed cell death
In the presence of cycloheximide (CHX) to inhibit protein synthesis, a high concentration of staurosporine (STS) induces almost all cells in explant cultures of 8/8 types of newborn mouse organs andExpand
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Experimental analysis of the transdifferentiation of visceral to parietal endoderm in the mouse
The visceral endoderm (VE) of isolated extraembryonic regions (ExEmbs) of 7 days postcoitum (dpc) prestreak mouse conceptuses have been shown to convert readily to parietal endoderm (PE). The presentExpand
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Human induced pluripotent stem cells are capable of B-cell lymphopoiesis.
Induced pluripotent stem (iPS) cells offer a unique potential for understanding the molecular basis of disease and development. Here we have generated several human iPS cell lines, and we describeExpand
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An investigation of the origin and significance of bilateral symmetry of the pronuclear zygote in the mouse.
BACKGROUND Preliminary observations revealed that advanced zygotes of the PO strain mouse are often bilaterally symmetrical, and suggested that both the plane of first cleavage and features of theExpand
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Directed Differentiation of Human Induced Pluripotent Stem Cells into Dendritic Cells Displaying Tolerogenic Properties and Resembling the CD141+ Subset
The advent of induced pluripotent stem cells (iPSCs) has begun to revolutionize cell therapy by providing a convenient source of rare cell types not normally available from patients in sufficientExpand
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Lack of coupling between onset of giant transformation and genome endoreduplication in the mural trophectoderm of the mouse blastocyst.
Prominent among the various types of cell that differentiate from the trophectoderm of the mouse blastocyst are trophoblastic giant cells. Repeated endoreduplication of the genome accompanies theExpand
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The basis and significance of pre-patterning in mammals.
  • R. Gardner, T. Davies
  • Biology, Medicine
  • Philosophical transactions of the Royal Society…
  • 29 August 2003
The second polar body (Pb) provides an enduring marker of the animal pole of the zygote, thereby revealing that the axis of bilateral symmetry of the early blastocyst is aligned with the zygote'sExpand
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Antimitogenic and mitogenic actions of interleukin-1 in diverse cell types are associated with induction of gro gene expression.
Interleukin-1 (IL-1) is an antiproliferative factor for growing human melanoma A375-C6 cells. To define the molecular basis for the action of IL-1, we set out to identify early genes induced by theExpand
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Is the plane of first cleavage related to the point of sperm entry in the mouse?
The notion that pattern formation cannot depend on cues that are already present in the zygote has dominated thinking about early development in mammals for more than 3 decades. However, recentExpand
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