T. D. Otto

Publications148
h-index44
Citations10,109
Highly Influential Citations711
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • M. Berriman
  • 223 Publications, 20,827 Citations
  • C. Newbold
  • 189 Publications, 14,748 Citations
  • M. Sanders
  • 121 Publications, 13,948 Citations
  • J. Rayner
  • 167 Publications, 8,131 Citations
  • Publications
  • Influence
A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers
BackgroundNext generation sequencing (NGS) technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been… Expand
  • 1,688
  • 103
  • PDF
REAPR: a universal tool for genome assembly evaluation
Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked. Here we present REAPR, a tool… Expand
  • 366
  • 60
  • PDF
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species
TLDR
We provided a variety of sequence data to be assembled for three vertebrate species (a bird, a fish, and snake). Expand
  • 646
  • 38
  • PDF
Circlator: automated circularization of genome assemblies using long sequencing reads
The assembly of DNA sequence data is undergoing a renaissance thanks to emerging technologies capable of producing reads tens of kilobases long. Assembling complete bacterial and small eukaryotic… Expand
  • 353
  • 38
  • PDF
RATT: Rapid Annotation Transfer Tool
Second-generation sequencing technologies have made large-scale sequencing projects commonplace. However, making use of these datasets often requires gene function to be ascribed genome wide.… Expand
  • 264
  • 34
  • PDF
A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni
Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people in developing countries. Amongst the human-infective species, Schistosoma mansoni is also the most… Expand
  • 324
  • 33
  • PDF
Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Leishmania parasites cause a spectrum of clinical pathology in humans ranging from disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference genome for Leishmania… Expand
  • 320
  • 28
Genomic Insights into the Origin of Parasitism in the Emerging Plant Pathogen Bursaphelenchus xylophilus
Bursaphelenchus xylophilus is the nematode responsible for a devastating epidemic of pine wilt disease in Asia and Europe, and represents a recent, independent origin of plant parasitism in… Expand
  • 286
  • 22
  • PDF
A cascade of DNA binding proteins for sexual commitment and development in Plasmodium
Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular mechanism(s) responsible… Expand
  • 267
  • 22
  • PDF
New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq
Recent advances in high‐throughput sequencing present a new opportunity to deeply probe an organism's transcriptome. In this study, we used Illumina‐based massively parallel sequencing to gain new… Expand
  • 277
  • 21
  • PDF