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Prediction of central nervous system embryonal tumour outcome based on gene expression
It is demonstrated that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours, atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas, and it is shown that the clinical outcome of children with medullOBlastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis.
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.
It is suggested that the Fos/Jun and ATF/CREB families of transcription factors, which function in coupling extracellular signals to alterations in expression of specific target genes, can be grouped into a superfamily of transcription factor.
A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
- G. D’Arcangelo, G. Miao, Shu-Cheng Chen, Holly D. Scares, J. Morgan, T. Curran
- 20 April 1995
The reeler phenotype seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin.
Reelin Is a Ligand for Lipoprotein Receptors
Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse
High-resolution in situ hybridization analyses to determine the pattern of reelin expression in the developing forebrain of the mouse revealed a complex pattern of cellular and regional expression that is consistent with Reelin having multiple roles in brain development and adult brain function.
Redox regulation of fos and jun DNA-binding activity in vitro.
DNA binding of the Fos-Jun heterodimer was modulated by reduction-oxidation of a single conserved cysteine residue in the DNA-binding domains of the two proteins, suggesting that transcriptional activity mediated by AP-1 binding factors may be regulated by a redox mechanism.
Radial glia cells are candidate stem cells of ependymoma.
Expression of c-fos protein in brain: metabolic mapping at the cellular level.
Fos immunohistochemistry provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways in response to polysynaptic activation.
Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice
The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and mDab1 function as signalling molecules that regulate cell positioning in the developing brain.