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Maternal nutrition and fetal development.
Nutrition is the major intrauterine environmental factor that alters expression of the fetal genome and may have lifelong consequences. This phenomenon, termed "fetal programming," has led to theExpand
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Animal Model Systems for the Study of Alcohol Teratology
  • T. Cudd
  • Biology, Medicine
  • Experimental biology and medicine
  • 1 June 2005
The incidence of fetal alcohol syndrome has not been declining even though alcohol has been established as a teratogen and significant efforts have been made to educate women not to abuse alcoholExpand
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Pharmacokinetics and safety of arginine supplementation in animals.
Anticipating the future use of arginine to enhance fetal and neonatal growth as well as to treat diabetes and obesity, we performed studies in pigs, rats, and sheep to determine the pharmacokineticsExpand
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Third trimester binge ethanol exposure results in fetal hypercapnea and acidemia but not hypoxemia in pregnant sheep.
BACKGROUND The mechanisms by which maternal ethanol abuse during pregnancy causes neurodevelopmental injury in the fetus are not well understood. The purpose of this study was to use a chronicallyExpand
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Ontogeny and ultradian rhythms of adrenocorticotropin and cortisol in the late-gestation fetal horse.
Fetal maturation and the timing of parturition in both sheep and primates are thought to be controlled by the hypothalamic-pituitary-adrenal axis but little is known about the endocrinology of theExpand
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Chronic ethanol increases fetal cerebral blood flow specific to the ethanol‐sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model
Cerebral hypoxia has been proposed as a mechanism by which prenatal ethanol exposure causes fetal alcohol spectrum disorder (FASD) in children, but no study had tested this hypothesis using a chronicExpand
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Physiological responses of mature Quarter Horses to reining training when fed conventional and fat-supplemented diets
Summary An initial experiment (Experiment I) was conducted utilizing five mature Quarter Horses to establish baseline physiological responses to typical reining training. In an initial standardizedExpand
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Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes.
Intrauterine growth restriction (IUGR) is a major health problem worldwide that currently lacks an effective therapeutic solution. This study was conducted with an ovine IUGR model to test theExpand
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Parenteral administration of L-arginine enhances fetal survival and growth in sheep carrying multiple fetuses.
The frequency of multiple fetuses has increased in human pregnancies due to assisted reproductive technologies. This translates into a greater proportion of premature and low-birth weight infants inExpand
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Alcohol-mediated Purkinje cell loss in the absence of hypoxemia during the third trimester in an ovine model system.
BACKGROUND Although the mechanisms that underlie fetal alcohol-induced neuronal loss have not been determined, hypoxia/hypoxemia has been considered a leading candidate. This study was designed toExpand
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